PMID- 9118837
OWN - NLM
STAT- MEDLINE
DCOM- 19970424
LR  - 20190721
IS  - 0013-4694 (Print)
IS  - 0013-4694 (Linking)
VI  - 105
IP  - 1
DP  - 1997 Feb
TI  - Motor evoked responses to paired cortical magnetic stimulation in Parkinson's 
      disease.
PG  - 37-43
AB  - We evaluated cortical excitability in patients with Parkinson's disease (PD) 
      using paired magnetic stimulation. This recent technique allows to study the 
      cortical inhibition after motor evoked potential (MEP) and its modulation at 
      different intensities of stimulation and interstimulus intervals (ISIs). At low 
      stimulus intensity and at ISIs of 40-75 ms we observed, in PD patients, a greater 
      test MEP inhibition, which might be due to a lower facilitatory effect of 
      conditioning MEP on the motor cortex. At high stimulus intensity, in PD patients, 
      a consistent inhibition of test MEP persisted and, at ISIs of 75-150 ms, it did 
      not reach the amplitude of conditioning MEP as in normal subjects. Some clinical 
      and neurophysiological features, like a silent period of shorter duration, 
      demonstrated in PD patients a decrease of the inhibitory input to the motor 
      cortex. On the contrary, the persistence of test-MEP inhibition at high stimulus 
      intensity could also suggest a prevalence of inhibitory activity when an 
      effective and phasic activation of the corticospinal system is required.
FAU - Valzania, F
AU  - Valzania F
AD  - Divisione Neurologica, Ospedale Bellaria, Universita di Bologna, Italy.
FAU - Strafella, A P
AU  - Strafella AP
FAU - Quatrale, R
AU  - Quatrale R
FAU - Santangelo, M
AU  - Santangelo M
FAU - Tropeani, A
AU  - Tropeani A
FAU - Lucchi, D
AU  - Lucchi D
FAU - Tassinari, C A
AU  - Tassinari CA
FAU - De Grandis, D
AU  - De Grandis D
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Electroencephalogr Clin Neurophysiol
JT  - Electroencephalography and clinical neurophysiology
JID - 0375035
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Aged
MH  - Cerebral Cortex/*physiopathology
MH  - Differential Threshold
MH  - Electric Stimulation/methods
MH  - *Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Levodopa/therapeutic use
MH  - Magnetics
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/drug therapy/*physiopathology
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1016/s0924-980x(96)96517-0 [doi]
PST - ppublish
SO  - Electroencephalogr Clin Neurophysiol. 1997 Feb;105(1):37-43. doi: 
      10.1016/s0924-980x(96)96517-0.