PMID- 9119708
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20041117
IS  - 0018-2052 (Print)
IS  - 0018-2052 (Linking)
VI  - 45
IP  - 4
DP  - 1996 Dec
TI  - Neutral endopeptidase activity in serum and cerebrospinal fluid.
PG  - 109-12
AB  - We measured neutral endopeptidase (NEP) activity in serum from non-smoking 
      healthy Japanese and in cerebrospinal fluid (CSF) from patients without 
      neurological or inflammatory diseases. The serum NEP activity (sNEP) of 25 males 
      and 25 females, aged 20 to 65 years, ranged from 0.003 to 1.62 
      pmole/min/microliter. There was no significant difference in sNEP activity 
      between the sexes (male: 0.40 +/- 0.34 pmol/min/microliter vs female: 0.37 +/- 
      0.30, mean +/- S.D.). There was a significant positive correlation (p < 0.05) 
      between sNEP and age. The NEP activity in the CSF (cNEP) ranged from 0.07 to 0.63 
      pmole/min/microliter. Male patients with benign prostate hypertrophy (BPH) showed 
      cNEP activity of 0.21 +/- 0.11 pmol/min/microliter (n = 13), and female patients 
      with myoma uteri (MU) or dysplasia of the uterus mucosa (DUM) showed activity of 
      0.32 +/- 0.20 (n = 5). There was no significant difference in cNEP activity 
      between the sexes. Three patients with severe body pain showed cNEP activity of 
      0.21, 0.15, and 0.16 pmole/min/microliter, and these values were dissimilar from 
      those of the BPH, MU, or DUM patients.
FAU - Muraki, K
AU  - Muraki K
AD  - Department of Pediatrics, Saiseikai Hiroshima Hospital, Japan.
FAU - Nakata, Y
AU  - Nakata Y
FAU - Simonaka, H
AU  - Simonaka H
FAU - Inoue, J
AU  - Inoue J
FAU - Hirai, Y
AU  - Hirai Y
FAU - Akiyama, M
AU  - Akiyama M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Hiroshima J Med Sci
JT  - Hiroshima journal of medical sciences
JID - 0421060
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neprilysin/blood/cerebrospinal fluid
MH  - Pain/blood/cerebrospinal fluid
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
PST - ppublish
SO  - Hiroshima J Med Sci. 1996 Dec;45(4):109-12.