PMID- 9120348
OWN - NLM
STAT- MEDLINE
DCOM- 19970424
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 71
IP  - 2
DP  - 1997 Feb
TI  - Retrospective biodosimetry of Chernobyl clean-up workers using chromosome 
      painting and conventional chromosome analysis.
PG  - 119-27
AB  - Blood samples of 52 Chernobyl clean-up workers were analysed by fluorescence in 
      situ hybridization (FISH) using whole-chromosome painting probes for chromosomes 
      1, 4 and 12, simultaneously with a pancentromeric probe and by conventional 
      chromosome analysis, for radiation-induced symmetrical translocations and 
      dicentrics in T-lymphocytes. Based on FISH measurements of translocations, 
      individual biodosimetry estimates between 0.32 and 1.0 Gy were obtained from 18 
      cases. Pooled data for the total group of 52 workers provided a collective 
      biodosimetry estimate of 0.23 Gy. For a group of 34 workers with documented 
      doses, the mean dose estimate of 0.25 Gy compared well with the mean documented 
      dose of 0.26 Gy. However, no correlation between individual translocation 
      frequencies (FG) and documented doses could be found. A statistical analysis of 
      the expected dose-response suggests exposures to higher doses than documented for 
      a substantial fraction of workers with ascribed doses < 0.2 Sv. For subjects 
      working repeatedly at the reactor site between 1986 and 1995 the mean 
      translocation frequency was significantly higher than for those working only in 
      1986. A comparison of dicentric frequencies obtained by conventional scoring and 
      by FISH measurements showed no significant difference, although only two of 52 
      cases revealed significantly higher yields than the mean control level. Based on 
      conventionally scored dicentric frequencies, a collective biodosimetry estimate 
      of 0.23 Gy could be derived only of the group of persons working at Chernobyl 
      exclusively in 1986 for which a documented average dose of 0.19 Gy was reported.
FAU - Snigiryova, G
AU  - Snigiryova G
AD  - Moscow Research Institute of Diagnostic and Surgery, Department of Radiation 
      Medicine, Russia.
FAU - Braselmann, H
AU  - Braselmann H
FAU - Salassidis, K
AU  - Salassidis K
FAU - Shevchenko, V
AU  - Shevchenko V
FAU - Bauchinger, M
AU  - Bauchinger M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cells, Cultured
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Power Plants
MH  - Radiation Dosage
MH  - Radiation Monitoring/*methods
MH  - *Radioactive Hazard Release
MH  - Translocation, Genetic
MH  - Ukraine
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1080/095530097144247 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1997 Feb;71(2):119-27. doi: 10.1080/095530097144247.