PMID- 9120486
OWN - NLM
STAT- MEDLINE
DCOM- 19970424
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 137
IP  - 1
DP  - 1996 Apr
TI  - An encephalitic episode in a multiple sclerosis patient with human herpesvirus 6 
      latent infection.
PG  - 42-6
AB  - All the human herpesviruses may cause central nervous system (CNS) diseases, 
      including benign aseptic meningitis or fatal encephalitis. It has recently been 
      stated that human herpesvirus 6 (HHV-6) may also be neuropathogenic in children 
      after primary infection, while in the adult, cases of fatal encephalitis have 
      been reported only in immune-compromised hosts such as AIDS patients, and in one 
      case of an immunosuppressed bone marrow transplant patient. We describe a 
      multiple sclerosis (MS) patient, carrier of HHV-6 latent infection, who 
      experienced an acute inflammation of the CNS diagnosed as encephalitis. HHV-6 
      specific genomic sequences have been detected by PCR in the patient's PBMCs DNA 
      collected before and during the encephalitis. The PCR performed in the CSF in 
      course of the acute episode was positive, while the CSF collected before the 
      encephalitis was negative. This finding is consistent with an acute 
      encephalopathy caused by the reactivation of a HHV-6 latent infection within the 
      CNS, in a patient with altered immune response due to MS.
FAU - Merelli, E
AU  - Merelli E
AD  - Neurology Department, University of Modena, Italy.
FAU - Sola, P
AU  - Sola P
FAU - Barozzi, P
AU  - Barozzi P
FAU - Torelli, G
AU  - Torelli G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Blotting, Southern
MH  - Carrier State/virology
MH  - DNA, Viral/analysis
MH  - Encephalitis, Viral/*complications
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/complications/*virology
MH  - Polymerase Chain Reaction
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 0022510X9500319W [pii]
AID - 10.1016/0022-510x(95)00319-w [doi]
PST - ppublish
SO  - J Neurol Sci. 1996 Apr;137(1):42-6. doi: 10.1016/0022-510x(95)00319-w.