PMID- 9121608
OWN - NLM
STAT- MEDLINE
DCOM- 19970423
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 35
IP  - 8
DP  - 1996
TI  - The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive 
      NMDA antagonist in active avoidance and lever-press learning tasks in mice.
PG  - 1057-64
AB  - The neurosteroid pregnenolone sulfate (PREG-S) has been shown to modulate 
      positively NMDA receptor activity and to have memory enhancing properties in 
      mice. The present study was designed to evaluate the effects of post-training 
      administration of PREG-S, alone or in combination with 
      D-2-amino-5-phosphonovalerate (D-AP5), a competitive NMDA receptor antagonist, in 
      Y-maze avoidance and appetitively motivated lever-press learning tasks and in a 
      traction reflex test in mice. Intracerebroventricular (i.c.v.) administration of 
      PREG-S (0.01-0.1 nmol/mouse) blocked the selective retention deficits induced by 
      0.02 nmol D-AP5 in the Y-maze avoidance task. PREG-S (0.1 nmol, i.c.v.) also 
      blocked the retention deficits induced by 0.02 nmol D-AP5 in the lever-press 
      task. Post-training administration of PREG-S alone (0.001-0.1 nmol, i.c.v.) had 
      no effect on retention performance in the Y-maze and the lever-press tasks. 
      PREG-S (1-10 nmol, i.c.v.) significantly reduced the impairment of the traction 
      reflex induced by 2 nmol D-AP5. The ability of PREG-S to block retention 
      performance deficits as well as motor impairment induced by D-AP5 is in agreement 
      with its positive modulatory action at NMDA receptors.
FAU - Mathis, C
AU  - Mathis C
AD  - Laboratoire de Psychophysiologie, URA 1295 CNRS, Universite Louis Pasteur, 
      Strasbourg, France.
FAU - Vogel, E
AU  - Vogel E
FAU - Cagniard, B
AU  - Cagniard B
FAU - Criscuolo, F
AU  - Criscuolo F
FAU - Ungerer, A
AU  - Ungerer A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 73R90F7MQ8 (Pregnenolone)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Binding, Competitive/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Memory/drug effects
MH  - Mice
MH  - Pregnenolone/administration & dosage/*pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Reflex/drug effects
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - S002839089600041X [pii]
AID - 10.1016/s0028-3908(96)00041-x [doi]
PST - ppublish
SO  - Neuropharmacology. 1996;35(8):1057-64. doi: 10.1016/s0028-3908(96)00041-x.