PMID- 9121744
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20220318
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 102
IP  - 7
DP  - 1995 Jul
TI  - Association between Vogt-Koyanagi-Harada syndrome and HLA-DR1 and -DR4 in 
      Hispanic patients living in southern California.
PG  - 1012-5
AB  - BACKGROUND: Vogt-Koyanagi-Harada (VKH) syndrome is associated with human 
      leukocyte antigen (HLA)-B54, -DR4, -DR beta 1*0405, -DQ4, and -DR53 in Japanese 
      patients. Disease-associated HLA specificities may differ among races. This study 
      examined HLA associations with VKH syndrome in Hispanic patients living in 
      southern California, a racial subgroup at increased risk for the disease. 
      METHODS: Human leukocyte antigen specificities were determined on 25 Hispanic 
      patients with VKH syndrome and compared with HLA specificities of 217 healthy 
      Hispanic control subjects. Inclusion criteria for study patients were 
      nontraumatic panuveitis with exudative retinal detachments, with or without 
      extraocular manifestations. Tests were performed using standard cytotoxic assays. 
      RESULTS: HLA-DR4 was present in 14 (56%) patients with VKH syndrome and in 
      62(29%) control subjects (relative risk = 1.96). HLA-DR1 was present in 9 (36%) 
      patients with VKH syndrome and in 19 (9%) control subjects (relative risk = 
      4.11). HLA-DR1 and DR4 share a common epitope within the DR beta 1 gene. HLA-DR1 
      and/or DR4 were present in 21 (84%) patients with VKH syndrome and in 76 (35%) 
      control subjects (relative risk = 2.40). CONCLUSIONS: HLA-DR1 and -DR4 were found 
      in a significantly disproportionate number of Hispanic patients with VKH syndrome 
      living in southern California. HLA-DR4, although not HLA-DR1, has been previously 
      associated with VKH syndrome in other groups. These associations suggest a common 
      immunogenic predisposition to VKH among different racial groups, and suggest that 
      a common epitope shared by DR1 and DR4 may be involved in the pathogenesis of the 
      disease.
FAU - Weisz, J M
AU  - Weisz JM
AD  - UCLA Ocular Inflammatory Disease Center, Jules Stein Eye Institute, Los Angeles, 
      CA 90095-7003, USA.
FAU - Holland, G N
AU  - Holland GN
FAU - Roer, L N
AU  - Roer LN
FAU - Park, M S
AU  - Park MS
FAU - Yuge, A J
AU  - Yuge AJ
FAU - Moorthy, R S
AU  - Moorthy RS
FAU - Forster, D J
AU  - Forster DJ
FAU - Rao, N A
AU  - Rao NA
FAU - Terasaki, P I
AU  - Terasaki PI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (HLA-DR1 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - California/epidemiology
MH  - Central America/ethnology
MH  - Female
MH  - HLA-DR1 Antigen/*immunology
MH  - HLA-DR4 Antigen/*immunology
MH  - Hispanic or Latino
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Mexico/ethnology
MH  - Risk Factors
MH  - Uveomeningoencephalitic Syndrome/ethnology/*immunology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - S0161-6420(95)30920-7 [pii]
AID - 10.1016/s0161-6420(95)30920-7 [doi]
PST - ppublish
SO  - Ophthalmology. 1995 Jul;102(7):1012-5. doi: 10.1016/s0161-6420(95)30920-7.