PMID- 9121746
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20190726
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 102
IP  - 7
DP  - 1995 Jul
TI  - Allograft conjunctival transplantation for bilateral ocular surface disorders.
PG  - 1020-5
AB  - PURPOSE: The purpose of this study is to evaluate the efficacy of allogenic 
      conjunctival transplantation in bilateral surface disorders and to correlate with 
      human leukocyte antigen (HLA) typing and cross-matching. METHODS: A prospective 
      study of allogenic conjunctival transplantation was undertaken in 12 eyes of 10 
      patients with bilateral surface disorders. Five eyes had Stevens-Johnson 
      syndrome, three had Lyell syndrome, three had bilateral alkali burns, and one had 
      a bilateral thermal burn. Human leukocyte antigen typing and cross-matching were 
      retrospectively performed in eight patients and their respective donors. 
      Stabilization of corneal epithelia, visual acuity, and rejection episodes were 
      examined after the procedure. RESULTS: Eleven (91.6%) of 12 eyes had improved 
      visual acuity, corneal transparency and surface lubrication, stabilization of 
      corneal epithelia, and decreased corneal neovascularization and photophobia after 
      an average follow-up of 17.2 months. Three patients (25%) had rejection episodes, 
      with no disturbance in corneal surface in two. Two of these three patients had 
      100% incompatible HLA donor-recipient pairs; HLA of the third patient was not 
      available. Patients with favorable evolution were either HLA identical or 
      haplo-identical (50% identity) with their donors. Donor eyes did not present any 
      epithelial problems during the follow-up period. CONCLUSIONS: Human leukocyte 
      antigen-matched allogenic conjunctival transplantation proved to be an adequate 
      method of treating severe bilateral surface disorders, with minimal 
      complications.
FAU - Kwitko, S
AU  - Kwitko S
AD  - Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil.
FAU - Marinho, D
AU  - Marinho D
FAU - Barcaro, S
AU  - Barcaro S
FAU - Bocaccio, F
AU  - Bocaccio F
FAU - Rymer, S
AU  - Rymer S
FAU - Fernandes, S
AU  - Fernandes S
FAU - Neumann, J
AU  - Neumann J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Conjunctiva/immunology/*transplantation
MH  - Corneal Diseases/etiology/physiopathology/*surgery
MH  - Epithelium/immunology/transplantation
MH  - Female
MH  - Graft Rejection/etiology/physiopathology
MH  - HLA Antigens/analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - S0161-6420(95)30918-9 [pii]
AID - 10.1016/s0161-6420(95)30918-9 [doi]
PST - ppublish
SO  - Ophthalmology. 1995 Jul;102(7):1020-5. doi: 10.1016/s0161-6420(95)30918-9.