PMID- 9124058
OWN - NLM
STAT- MEDLINE
DCOM- 19970418
LR  - 20190914
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 39
IP  - 1
DP  - 1997 Feb
TI  - A case retaining contact urticaria against egg white after gaining tolerance to 
      ingestion.
PG  - 69-73
AB  - A girl, 5.7 years old, gained tolerance to egg white ingestion in spite of high 
      immunoglobulin E (IgE) antibody titers to egg white but retained contact 
      urticaria against egg white. She developed atopic dermatitis on her face at 2 
      months of age and showed high IgE antibody titers to egg white and cow's milk. 
      Accidental ingestion of egg products initiated immediate symptoms such as 
      wheezing, urticaria, erythema and edema of the eyelids and conjunctiva three 
      times. These symptoms were confirmed by challenge tests using boiled egg white at 
      3.9 years of age. She also reacted positively to a 20 min patch test on her volar 
      arm with raw egg white. However, there were no reactions to the oral challenge 
      test by boiled egg and freeze-dried egg white at 5.1 and 5.7 years of age, 
      respectively. This non-responsiveness was confirmed by a double-blind, 
      placebo-controlled food challenge using freeze-dried egg white. Nevertheless, she 
      showed positive reactions to a 20 min patch test with freeze-dried egg white. Her 
      IgE antibody titers to the egg white components including ovomucoid, ovalbumin, 
      ovotransferrin and lysozyme as well as egg white were high from 2.9 to 5.7 years 
      old. Her IgE antibody titers for the ovomucoid fragments digested by pepsin, 
      chymotrypsin and trypsin were not lower than those of positive control subjects. 
      The binding activity of IgE antibody to ovomucoid, however, decreased from 2.9 to 
      5.6 years as shown by radioallergosorbent test (RAST) inhibition assays. The IgE 
      antibody showed weaker binding activity to pepsin- and chymotrypsin-digested 
      ovomucoid that were filtered through cut-off 10,000 filter at the age of 2.1 and 
      5.7 years. We speculated that the maturation of secretion of digestive enzymes 
      was involved in the mechanisms of the acquisition of tolerance to egg white 
      ingestion in spite of the persistence of contact urticaria.
FAU - Yamada, K
AU  - Yamada K
AD  - Department of Pediatrics, Biyoh Hospital, Aichi, Japan.
FAU - Urisu, A
AU  - Urisu A
FAU - Haga, Y
AU  - Haga Y
FAU - Matsuoka, H
AU  - Matsuoka H
FAU - Komada, H
AU  - Komada H
FAU - Torii, S
AU  - Torii S
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibody Affinity
MH  - Child
MH  - Egg White/*adverse effects
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunoglobulin E/immunology
MH  - Radioallergosorbent Test
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1111/j.1442-200x.1997.tb03559.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1997 Feb;39(1):69-73. doi: 10.1111/j.1442-200x.1997.tb03559.x.