PMID- 9124453
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20180109
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 272
IP  - 2 Pt 2
DP  - 1997 Feb
TI  - Hypothyroid-induced changes in autonomic control have a central serotonergic 
      component.
PG  - H894-903
AB  - Three experiments were conducted in unanesthetized rats made hypothyroid (Hypo) 
      or maintained as euthyroid controls (Eu) to examine general cardiovascular 
      responsiveness [experiment I (Exp I)]; responsiveness to a serotonin (5-HT2) 
      agonist, dl-2,5-dimethoxy-4-iodoamphetamine [DOI intracerebroventricularly; 
      experiment II (Exp II)]; or responsiveness to a 5-HT(1A) agonist 
      dl-8-hydroxydipropyl-aminotetralin hydrobromide [8-OH-DPAT 
      intracerebroventricularly; experiment III (Exp III)]. In Exp I, intravenous 
      infusions of phenylephrine and nitroprusside provided little evidence that 
      findings in Exp II and III were caused by generalized impairment in 
      cardiovascular responsiveness in Hypo. In Exp II and III, Eu and Hypo were given 
      either intra-arterial atropine or vehicle. Atropine significantly elevated heart 
      rate (Exp II and III) and mean arterial pressure (Exp II) in Eu only. When 
      compared with Eu, Hypo had a reduced pressor response (5.2 vs. 20.1%), an 
      attenuated pulse pressure response (19.3 vs. 35.4%), and a more robust 
      bradycardia (-17.7 vs. -7.0%) in response to DOI. These differences were atropine 
      sensitive. In Exp III, Hypo had larger decrements in mean arterial pressure (-9.0 
      vs. -5.1%), heart rate ( -13.9 vs. - 7.7%), and body temperature (-4.5 vs. -2.7%) 
      in response to 8-OH-DPAT in comparison to Eu. Parasympathetic involvement in the 
      differential responses to 8-OH-DPAT was less clear than with DOI. Deranged 
      autonomic control in hypothyroidism may be caused, in part, by changes in central 
      serotonergic activity.
FAU - Henley, W N
AU  - Henley WN
AD  - Department of Biological Sciences and College of Osteopathic Medicine, Ohio 
      University, Athens 45701, USA.
FAU - Vladic, F
AU  - Vladic F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Amphetamines)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - 7C0697DR9I (Atropine)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Atropine/pharmacology
MH  - Autonomic Nervous System/*physiopathology
MH  - Blood Pressure/drug effects
MH  - Body Temperature/drug effects
MH  - Brain/physiology
MH  - Cardiovascular System
MH  - Heart Rate/drug effects
MH  - Hypothyroidism/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reference Values
MH  - Serotonin/*physiology
MH  - Serotonin Receptor Agonists/pharmacology
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1152/ajpheart.1997.272.2.H894 [doi]
PST - ppublish
SO  - Am J Physiol. 1997 Feb;272(2 Pt 2):H894-903. doi: 
      10.1152/ajpheart.1997.272.2.H894.