PMID- 9125128
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20151119
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 232
IP  - 1
DP  - 1997 Mar 6
TI  - Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.
PG  - 188-91
AB  - We investigated the effect of methyleugenol on anaphylaxis. Methyleugenol 
      completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. 
      Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl 
      (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release 
      in mast cells activated by compound 48/80 or anti-DNP IgE. Northern-blot analysis 
      demonstrated that significantly reduced level of the mRNA of L-histidine 
      decarboxylase (HDC) was expressed in mast cells treated with methyleugenol, 
      compared to that without methyleugenol. We conclude that methyleugenol directly 
      affect histamine release and HDC gene over-expression in mast cells.
FAU - Shin, B K
AU  - Shin BK
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (RNA, Messenger)
RN  - 29T9VA6R7M (methyleugenol)
RN  - 33507-63-0 (Substance P)
RN  - 3T8H1794QW (Eugenol)
RN  - EC 4.1.1.22 (Histidine Decarboxylase)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Eugenol/*analogs & derivatives/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Histidine Decarboxylase/*genetics
MH  - Mast Cells/enzymology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - RNA, Messenger/*genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Substance P/pharmacology
EDAT- 1997/03/06 00:00
MHDA- 1997/03/06 00:01
CRDT- 1997/03/06 00:00
PHST- 1997/03/06 00:00 [pubmed]
PHST- 1997/03/06 00:01 [medline]
PHST- 1997/03/06 00:00 [entrez]
AID - S0006-291X(97)96260-4 [pii]
AID - 10.1006/bbrc.1997.6260 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1997 Mar 6;232(1):188-91. doi: 
      10.1006/bbrc.1997.6260.