PMID- 9130643
OWN - NLM
STAT- MEDLINE
DCOM- 19970522
LR  - 20171116
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 27
IP  - 4
DP  - 1997 Apr
TI  - Increased severity of experimental autoimmune encephalomyelitis, chronic 
      macrophage/microglial reactivity, and demyelination in transgenic mice producing 
      tumor necrosis factor-alpha in the central nervous system.
PG  - 905-13
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an inflammatory cytokine implicated in 
      a number of autoimmune diseases. Apoptotic cell death is induced by TNF-alpha in 
      vitro, and has been suggested as one cause of autoimmune pathology, including 
      autoimmune demyelinating diseases where oligodendrocytes are a target of immune 
      attack. TNF-alpha also regulates macrophage activity which could contribute to 
      autoimmune inflammation. We have expressed TNF-alpha at disease-equivalent levels 
      in the central nervous system of transgenic mice, using a myelin basic protein 
      (MBP) promoter. These mice were normal and showed no spontaneous pathology, but 
      they developed experimental autoimmune encephalomyelitis (EAE) with greater 
      severity than nontransgenic controls when immunized with MBP in adjuvant. Unlike 
      nontransgenic controls, EAE then progressed to a nonabating demyelinating 
      disease. Macrophage/microglial reactivity was evident in demyelinating lesions in 
      spinal cord, but T cells were not detected during chronic disease. The 
      participation of TNF-alpha in the demyelinating process is thus more probably due 
      to the perpetuation of macrophage/microglial activation than to direct 
      cytotoxicity of myelin or oligodendroglia.
FAU - Taupin, V
AU  - Taupin V
AD  - Montreal Neurological Institute, McGill University, Quebec, Canada.
FAU - Renno, T
AU  - Renno T
FAU - Bourbonniere, L
AU  - Bourbonniere L
FAU - Peterson, A C
AU  - Peterson AC
FAU - Rodriguez, M
AU  - Rodriguez M
FAU - Owens, T
AU  - Owens T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Macrophage-1 Antigen)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - Demyelinating Diseases/*pathology
MH  - Encephalomyelitis, Autoimmune, Experimental/*etiology/*immunology/pathology
MH  - Leukocyte Common Antigens/analysis
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophage-1 Antigen/analysis
MH  - Macrophages/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microglia/classification/*immunology/pathology
MH  - Molecular Weight
MH  - RNA, Messenger/biosynthesis
MH  - Spinal Cord/*metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/genetics
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1002/eji.1830270416 [doi]
PST - ppublish
SO  - Eur J Immunol. 1997 Apr;27(4):905-13. doi: 10.1002/eji.1830270416.