PMID- 9134889
OWN - NLM
STAT- MEDLINE
DCOM- 19970721
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 82
IP  - 5
DP  - 1997 May
TI  - TNF-alpha in smoke inhalation lung injury.
PG  - 1433-7
AB  - Adult respiratory distress syndrome is a major cause of morbidity in fire 
      victims. Tumor necrosis factor-alpha(TNF-alpha) is edematogenic and has been 
      associated with the etiology of other forms of adult respiratory distress 
      syndrome. In the sheep lymph fistula model, we measured TNF-alpha after 48 (n = 
      7) or 128 (n = 3) breaths of cotton smoke and compared this with sham controls (n 
      = 5) or controls in which left atrial pressure was elevated to 20 mmHg (n = 5) to 
      increase lymph flow in the absence of inflammation. Smoke induced a rise in lymph 
      flow and pulmonary arterial pressure with either no fall in lymph-to-plasma 
      protein ratio (128 breaths) or a modest fall in lymph-to-plasma protein ratio (48 
      breaths), consistent with a change in microvascular permeability as well as a 
      rise in microvascular pressure. Lymph concentration of TNF-alpha fell in both 
      groups, although lymph flux (concentration x flow) transiently rose in both. In 
      neither case did TNF-alpha flux exceed that induced by left atrial pressure 
      elevation. TNF-alpha was detectable in only one out of five sheep in alveolar 
      lavage. Thus, by utilizing a sensitive and specific radioimmunoassay, we were 
      unable to demonstrate a role for TNF-alpha in smoke-induced microvascular lung 
      injury in sheep.
FAU - Hales, C A
AU  - Hales CA
AD  - Department of Medicine, Massachusetts General Hospital, Shriners Burns Institute, 
      Boston, USA.
FAU - Elsasser, T H
AU  - Elsasser TH
FAU - Ocampo, P
AU  - Ocampo P
FAU - Efimova, O
AU  - Efimova O
LA  - eng
GR  - HL-36829/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Endotoxins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Atrial Function/physiology
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Endotoxins/pharmacology
MH  - Lung/*chemistry/metabolism
MH  - Lymph/chemistry/physiology
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Sheep
MH  - Smoke Inhalation Injury/*metabolism
MH  - Tumor Necrosis Factor-alpha/analysis/*metabolism
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1152/jappl.1997.82.5.1433 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1997 May;82(5):1433-7. doi: 10.1152/jappl.1997.82.5.1433.