PMID- 9137097
OWN - NLM
STAT- MEDLINE
DCOM- 19970520
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 150
IP  - 5
DP  - 1997 May
TI  - Pulmonary response to inhaled antigen: neuroimmune interactions promote the 
      recruitment of dendritic cells to the lung and the cellular immune response to 
      inhaled antigen.
PG  - 1735-43
AB  - Dendritic cells (DCs) play a critical role in capturing and presenting inhaled 
      antigens to T lymphocytes. We report that pulmonary DCs in the Lewis rat are 
      normally located in the lung in immediate proximity to nerve fibers that contain 
      immunoreactive substance P (SP). Functionally, pulmonary DCs bound 125I-SP and 
      displayed increased motility in vitro in response to graded concentrations of SP. 
      However, SP had no effect on the accessory cell activities of DCs. To examine the 
      role of neural influences on the pulmonary immune response to inhaled antigen, 
      Lewis rats were pretreated with capsaicin (CAP), which damages small nerves and 
      depletes neuropeptide stores, and then challenged intratracheally (i.t.) with hen 
      egg lysozyme (HEL). The number and antigen-presenting cell activities of 
      pulmonary DCs in the CAP-treated rats were comparable to those of controls up to 
      day 14. T lymphocytes harvested from the regional lymph nodes draining the lung 
      were effectively sensitized to HEL in both groups. However, when CAP-treated rats 
      sensitized to HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14, the 
      lungs showed decreased numbers of OX-6+ DCs and diminished pulmonary lymphoid 
      infiltrates compared with controls. We suggest that CAP interferes with a 
      neural-mediated response that contributes to the accumulation of inflammatory 
      cells during the efferent limb of the pulmonary-cell-mediated immune response in 
      vivo.
FAU - Kradin, R
AU  - Kradin R
AD  - Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
FAU - MacLean, J
AU  - MacLean J
FAU - Duckett, S
AU  - Duckett S
FAU - Schneeberger, E E
AU  - Schneeberger EE
FAU - Waeber, C
AU  - Waeber C
FAU - Pinto, C
AU  - Pinto C
LA  - eng
GR  - HL36781/HL/NHLBI NIH HHS/United States
GR  - HL48385/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Antigens)
RN  - 33507-63-0 (Substance P)
RN  - EC 3.2.1.17 (Muramidase)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Antigens/administration & dosage/*physiology
MH  - Capsaicin/pharmacology
MH  - Cell Movement/drug effects/immunology
MH  - Dendritic Cells/*immunology/pathology/physiology
MH  - Female
MH  - Immunity, Cellular/drug effects
MH  - Lung/*immunology/innervation
MH  - Muramidase/immunology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Substance P/immunology/physiology
PMC - PMC1858203
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
PMCR- 1997/11/01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PHST- 1997/11/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1997 May;150(5):1735-43.