PMID- 9138109
OWN - NLM
STAT- MEDLINE
DCOM- 19970702
LR  - 20190909
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 24
IP  - 4
DP  - 1997 Apr
TI  - Detection of numerical chromosomal aberrations in malignant melanomas using 
      fluorescence in situ hybridization.
PG  - 201-5
AB  - To evaluate the numerical chromosomal aberration in malignant melanoma, we have 
      applied fluorescence in situ hybridization (FISH) with repetitive DNA probes 
      specific for chromosomes 1, 6, 7, 9, 10, and 17 on 24 fresh malignant melanomas 
      (primary: 14, metastatic: 8). We defined a tumor that had copies with more than 3 
      spots as chromosomal gain. Chromosomal copy number gain was found in 40.9% of the 
      cases for chromosome 7, 27.2% for chromosome 6, 27.2% for chromosome 17, 22.7% 
      for chromosome 9 and 10, and 4.5% for chromosome 1. Monosomy was found in 54.5% 
      of the cases for chromosome 10, 36.5% for chromosome 9, 27.2% for chromosome 6, 
      22.7% for chromosome 17, and 18.1% for chromosome 1 and 7. The most frequent 
      numerical alterations were seen in chromosomes 6, 7, 9 and 10. Gain of chromosome 
      6 and 7 and/or losses of chromosome 9 and 10 may play an important role in the 
      tumorigenesis and development of malignant melanomas.
FAU - Matsuta, M
AU  - Matsuta M
AD  - Department of Dermatology, Iwate Medical University School of Medicine, Morioka, 
      Japan.
FAU - Imamura, Y
AU  - Imamura Y
FAU - Matsuta, M
AU  - Matsuta M
FAU - Sasaki, K
AU  - Sasaki K
FAU - Kon, S
AU  - Kon S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Centromere/chemistry/genetics/metabolism
MH  - Chromosome Aberrations/*genetics
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 6
MH  - *Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Gene Dosage
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*genetics
MH  - Middle Aged
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0560.1997.tb01581.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 1997 Apr;24(4):201-5. doi: 10.1111/j.1600-0560.1997.tb01581.x.