PMID- 9138441
OWN - NLM
STAT- MEDLINE
DCOM- 19970508
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 16
IP  - 3
DP  - 1997 Mar
TI  - Characterization of the disruptions of prepulse inhibition and habituation of 
      startle induced by alpha-ethyltryptamine.
PG  - 246-55
AB  - Alpha-ethyltryptamine (AET), a monoamine oxidase inhibitor and potent monoamine 
      releasing agent, has been sold illicitly as a substitute for the entactogen 
      3,4-methylenedioxy-N-methylamphetamine (MDMA), and is the first example of an 
      indolealkylamine analog demonstrated to substitute in MDMA-trained animals. 
      Previous studies have demonstrated that MDMA and AET have similar effects on 
      unconditioned motor behavior in rats. Furthermore, the locomotor-activating 
      effects of both MDMA and AET are blocked by pretreatment with fluoxetine, a 
      selective serotonin (5-HT) uptake inhibitor, suggesting that the two compounds 
      may share a presynaptic mechanism of action. This study examined the effects of 
      AET using measures of startle plasticity, specifically prepulse inhibition (PPI), 
      and habituation. PPI, a measure of sensorimotor gating, is reduced in rats 
      treated with hallucinogens, 5-HT releasers, and dopamine agonists. In contrast, 
      startle habituation is reduced in rats treated with hallucinogens and 5-HT 
      releasers. AET (1.25, 2.5, 5, and 10 mg/kg) decreased PPI of acoustic startle and 
      reduced the habituation of tactile startle. To determine whether AET produces 
      these effects via pre- or postsynaptic actions, fluoxetine (10 mg/kg) was used as 
      a pretreatment. By itself, fluoxetine did not disrupt PPI, but did reduce startle 
      habituation. Fluoxetine pretreatment prevented the AET-induced disruption of PPI 
      and reduced the AET-induced disruption of startle habituation. Combined with 
      previous findings, these results confirm that AET produces behavioral effects 
      that mimic those of other indirect 5-HT agonists and that the effects of AET on 
      startle plasticity are due to the release of presynaptic 5-HT.
FAU - Martinez, D L
AU  - Martinez DL
AD  - Department of Neuroscience, University of California, San Diego, La Jolla 
      92093-0804, USA.
FAU - Geyer, M A
AU  - Geyer MA
LA  - eng
GR  - K05MH01228/MH/NIMH NIH HHS/United States
GR  - R02DA02925/DA/NIDA NIH HHS/United States
GR  - R37MH42228/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Serotonin Receptor Agonists)
RN  - 0 (Tryptamines)
RN  - 01K63SUP8D (Fluoxetine)
RN  - GR181O3R32 (etryptamine)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Fluoxetine/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex, Startle/*drug effects
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Tryptamines/antagonists & inhibitors/*pharmacology
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0893133X96002400 [pii]
AID - 10.1016/S0893-133X(96)00240-0 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 1997 Mar;16(3):246-55. doi: 
      10.1016/S0893-133X(96)00240-0.