PMID- 9140557
OWN - NLM
STAT- MEDLINE
DCOM- 19970724
LR  - 20220331
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 58
IP  - 5
DP  - 1997 May
TI  - Relapsing bacteremia after blood transmission of Bartonella henselae to cats.
PG  - 492-7
AB  - OBJECTIVES: To determine persistence of bacteremia, pathogenicity, and 
      immunoglobulin kinetics after blood transmission of Bartonella henselae in cats. 
      ANIMALS: 18 specific-pathogen-free (SPF) cats (16 weeks old) received blood or 
      urine from 4 adult cats (2 SPF, 2 naturally infected with B henselae). PROCEDURE: 
      SPF cats were inoculated with blood IV (n = 4), blood IM (n = 4), or urine 
      sediment IM (n = 4) from 2 bacteremic cats (donors A and B). Control cats 
      (2/route) received inoculum from culture-negative, seronegative SPF cats (donors 
      C and D). RESULTS: 6 cats (5 blood, 1 urine) were transiently febrile during the 
      213-day observation period. Two bacteremic cats developed CNS abnormalities. 
      Transient anemia was the only hematologic abnormality. Bacteremia was induced in 
      7 of 8 blood recipients by postinoculation day (PID) 11. Urine recipients (n = 6) 
      did not become bacteremic or seroconvert by PID 108, but when challenge exposed 
      IV with blood, 4 of 6 became infected. All infected cats developed relapsing 
      bacteremia. Initially, colony counts for donor-A recipients were 10(3) greater 
      than those for donor-B recipients; however, during relapses, counts were similar. 
      Polymerase chain reaction-restriction fragment length polymorphism analysis of 
      16S rRNA gene and the intergenic spacer region revealed no differences among 
      isolates derived from recipient cats. Bartonella henselae-specific antibodies 
      were detected between PID 15 and 18 in donor-A, compared with PID 46 and 181 in 
      donor-B recipients. The peak geometric mean titer of donor-A recipients was 
      1,448, versus 406 for donor-B recipients. CONCLUSIONS AND CLINICAL RELEVANCE: 
      Blood transmission of B henselae induced subtle clinical abnormalities; the 
      biological behavior of the 2 donor strains differed; and relapsing bacteremia can 
      persist in conjunction with variably high antibody titers.
FAU - Kordick, D L
AU  - Kordick DL
AD  - Department of Companion Animal and Special Species Medicine, College of Veterinay 
      Medicine, North Carolina State University, Raleigh 27606, USA.
FAU - Breitschwerdt, E B
AU  - Breitschwerdt EB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (RNA, Bacterial)
RN  - 0 (RNA, Ribosomal, 16S)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/analysis/blood/immunology
MH  - Bacteremia/physiopathology/transmission/*veterinary
MH  - Bacteriuria/physiopathology/transmission/veterinary
MH  - Bartonella Infections/physiopathology/transmission/*veterinary
MH  - Bartonella henselae/genetics/immunology/*physiology
MH  - Cat Diseases/epidemiology/physiopathology/*transmission
MH  - Cats
MH  - Female
MH  - Fever/epidemiology/etiology/veterinary
MH  - Incidence
MH  - Male
MH  - Polymerase Chain Reaction/methods/veterinary
MH  - RNA, Bacterial/analysis/genetics
MH  - RNA, Ribosomal, 16S/analysis/genetics
MH  - Recurrence
MH  - Retrospective Studies
MH  - Specific Pathogen-Free Organisms
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1997 May;58(5):492-7.