PMID- 9141255
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20190914
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 39
IP  - 2
DP  - 1997 Apr
TI  - Bronchial hyper-responsiveness in atopic dermatitis.
PG  - 205-9
AB  - Most patients with atopic dermatitis (AD) have symptoms of asthma at some point 
      in their lives, but some do not have any clinical evidence of asthma. Thirty-two 
      patients with AD who had never suffered from bronchial asthma were investigated 
      by the methacholine inhalation test for the presence of bronchial 
      hyper-responsiveness (BHR). Serum immunoglobulin E (IgE) levels, mite specific 
      IgE antibody, peripheral eosinophil counts, serum levels of eosinophil cationic 
      proteins (ECP), and serum levels of major basic proteins (MBP) were determined 
      and a skin test to acetylcholine and adrenaline was performed. The percentage of 
      cases who showed BHR (minimum dose; Dmin < 50 units) was 31.3% in AD patients and 
      19.0% in 21 healthy controls. In those cases, Dmin of methacholine in AD was 
      significantly lower than that in the controls (P < 0.01). Serum MBP levels were 
      significantly higher in AD with BHR than in those without it (P < 0.05). These 
      results indicate that some AD patients without asthma have BHR, and it may be 
      related to serum MBP levels.
FAU - Miyabayashi, Y
AU  - Miyabayashi Y
AD  - Department of Pediatrics, Doai Memorial Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 0 (Blood Proteins)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Proteins/analysis
MH  - *Bronchial Hyperreactivity
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents/therapeutic use
MH  - Child
MH  - Dermatitis, Atopic/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Methacholine Chloride
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1111/j.1442-200x.1997.tb03582.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1997 Apr;39(2):205-9. doi: 10.1111/j.1442-200x.1997.tb03582.x.