PMID- 9141509
OWN - NLM
STAT- MEDLINE
DCOM- 19970523
LR  - 20220318
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 82
IP  - 5
DP  - 1997 May
TI  - Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role 
      of sleep disturbance and obesity.
PG  - 1313-6
AB  - Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the 
      general population and the chief complaint of the majority of patients at Sleep 
      Disorders Centers. There is evidence that the inflammatory cytokines tumor 
      necrosis factor-alpha (TNF alpha), interleukin-1beta (IL-1beta), and IL-6 are 
      involved in physiological sleep regulation and that their administration to 
      humans is associated with sleepiness and fatigue. To explore whether plasma 
      levels of TNF alpha, IL-1beta, and IL-6 are elevated in patients with EDS, we 
      measured morning plasma levels of TNF alpha, IL-1beta, and IL-6 in 12 sleep 
      apneics, 11 narcoleptics, 8 idiopathic hypersomniacs, and 10 normal controls. TNF 
      alpha was significantly elevated in sleep apneics and narcoleptics compared to 
      that in normal controls (P < 0.001 and P = 0.001, respectively). Plasma IL-1beta 
      concentrations were not different between sleep disorder patients and controls, 
      whereas IL-6 was markedly and significantly elevated in sleep apneics compared to 
      that in normal controls (P = 0.028). The primary factor influencing TNF alpha 
      values was the degree of nocturnal sleep disturbance, whereas the primary 
      determinant for IL-6 levels was the body mass index. Our findings suggest that 
      TNF alpha and IL-6 might play a significant role in mediating sleepiness and 
      fatigue in disorders of EDS in humans.
FAU - Vgontzas, A N
AU  - Vgontzas AN
AD  - Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA.
FAU - Papanicolaou, D A
AU  - Papanicolaou DA
FAU - Bixler, E O
AU  - Bixler EO
FAU - Kales, A
AU  - Kales A
FAU - Tyson, K
AU  - Tyson K
FAU - Chrousos, G P
AU  - Chrousos GP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - J Clin Endocrinol Metab. 1997 May;82(5):1311-2. PMID: 9141508
MH  - Adult
MH  - Body Mass Index
MH  - Cytokines/*blood
MH  - Disorders of Excessive Somnolence/blood
MH  - Female
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Narcolepsy/blood
MH  - Obesity/*blood
MH  - Sleep Apnea Syndromes/blood
MH  - Sleep Wake Disorders/*blood
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1210/jcem.82.5.3950 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1997 May;82(5):1313-6. doi: 10.1210/jcem.82.5.3950.