PMID- 9144357
OWN - NLM
STAT- MEDLINE
DCOM- 19970718
LR  - 20210526
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 4
IP  - 3
DP  - 1997 May
TI  - Value of detecting immunoglobulin E antibodies for the serological diagnosis of 
      Toxoplasma gondii infection.
PG  - 247-51
AB  - The presence of immunoglobulin E (IgE) antibodies was determined by using the 
      immunosorbent-agglutination assay (ISAGA) with 611 serum samples from patients 
      with different clinical conditions to evaluate its value for the serodiagnosis of 
      acute Toxoplasma gondii infection. By analyzing 43 consecutively drawn serum 
      samples from 10 pregnant women who seroconverted, we could show that specific IgE 
      antibodies seem to appear early after infection and are usually present for less 
      than 3 to 5 months. Therefore, we assumed that IgE antibodies seem to be 
      detectable only during the acute or reactivated stage of infection. According to 
      our studies, the IgE ISAGA has an overall sensitivity of only 79.5%, but a 
      specificity of 98.0%, with positive and negative predictive values of 95.5 and 
      89.8%, respectively. Detection of IgE antibodies in immunosuppressed patients 
      with reactivation of latent T. gondii infection correlates with disease activity. 
      Despite these encouraging results, one must note that IgE antibodies were not 
      detectable in 4 of 14 patients with very recent infection proven by 
      seroconversion. Therefore, detection of IgE antibodies seems to correlate with 
      early acute or reactivated toxoplasmosis, whereas negative IgE results do not 
      exclude the possibility of the acute stage of toxoplasmosis.
FAU - Gross, U
AU  - Gross U
AD  - Institute of Hygiene and Microbiology, University of Wurzburg, Germany. 
      ugross@hygiene.uni-wuerzburg.de
FAU - Keksel, O
AU  - Keksel O
FAU - Darde, M L
AU  - Darde ML
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Agglutination Tests/methods/statistics & numerical data
MH  - Animals
MH  - Antibodies, Protozoan/*blood
MH  - Antigens, Protozoan
MH  - Evaluation Studies as Topic
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunosorbent Techniques/statistics & numerical data
MH  - Liver Transplantation/adverse effects
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/diagnosis/immunology
MH  - Recurrence
MH  - Sensitivity and Specificity
MH  - Serologic Tests
MH  - Species Specificity
MH  - Toxoplasma/*immunology
MH  - Toxoplasmosis/complications/*diagnosis/immunology
MH  - Toxoplasmosis, Cerebral/diagnosis/immunology
PMC - PMC170512
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
PMCR- 1997/05/01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PHST- 1997/05/01 00:00 [pmc-release]
AID - 10.1128/cdli.4.3.247-251.1997 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 1997 May;4(3):247-51. doi: 10.1128/cdli.4.3.247-251.1997.