PMID- 9147128
OWN - NLM
STAT- MEDLINE
DCOM- 19970603
LR  - 20220318
IS  - 1357-2725 (Print)
IS  - 1357-2725 (Linking)
VI  - 29
IP  - 2
DP  - 1997 Feb
TI  - Retinoid X receptors.
PG  - 275-8
AB  - Retinoids are metabolites of retinol (vitamin A), which act as signalling 
      molecules in embryogenesis and as stimulators of cellular differentiation. The 
      potency of retinoids as differentiating agents has led to their successful use in 
      treating skin diseases and some forms of cancer. The retinoid X receptors (RXRs) 
      are receptors for the vitamin A metabolite 9-cis retinoic acid, and they are 
      members of the steroid/thyroid hormone receptor superfamily of DNA binding 
      nuclear hormone receptor. The RXRs are also cofactors required for transcription 
      activated by some other members of the steroid/thyroid hormone receptor 
      superfamily, including the all-trans retinoic acid, thyroid hormone, vitamin D 
      and peroxisome proliferator-activated receptors. The biological importance of the 
      RXRs has been demonstrated in recent genetic studies which have shown that some 
      RXR null mutations in mice have phenotypic effects similar to vitamin A 
      deficiency.
FAU - Rowe, A
AU  - Rowe A
AD  - Academic Therapeutics Department, Chelsea and Westminster Hospital, London, U.K.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Receptors, Retinoic Acid/*physiology
MH  - Retinoid X Receptors
MH  - Transcription Factors/*physiology
RF  - 11
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - S1357-2725(96)00101-X [pii]
AID - 10.1016/s1357-2725(96)00101-x [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 1997 Feb;29(2):275-8. doi: 
      10.1016/s1357-2725(96)00101-x.