PMID- 9147371
OWN - NLM
STAT- MEDLINE
DCOM- 19970723
LR  - 20221207
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 94
IP  - 1-3
DP  - 1997 Mar
TI  - HLA and longevity or aging among Shanghai Chinese.
PG  - 191-8
AB  - Twenty-two centenarians and one hundred and seventy-nine nonagenarians (mean age 
      93 +/- 1.04 years) in the Shanghai Region of China were phenotyped for alleles of 
      A (13 types), B (21 types) and C (6 types) loci of the human leukocyte antigen 
      (HLA). The frequencies of HLA antigens were compared with 211 healthy adults 
      whose ages ranged from 20 to 50 years. It was observed that A9 was highly 
      associated with longevity (frequency in the longevity group is 38%, the control 
      group 24%, P = 0.002). A30 showed marked inverse correlation (frequency in the 
      longevity group is 8%, the control group 17%, P = 0.008). Cw3, Cw6 and Cw7 were 
      also inversely correlated (P = 0.02, 0.04 and 0.02, respectively). Thus, it is 
      likely that A9 may contribute to longevity while A30, Cw3, Cw6 and Cw7 may be 
      associated with aging. The average superoxide dismutase (SOD) contents of 
      erythrocytes in 48 cases with the HLA-A9 (without A30) antigen in the longevity 
      group and in 13 cases with the HLA-A30 (without A9) antigen in the control group 
      were 555 +/- 96 and 593 +/- 58 micrograms/gHb, respectively (t = 1.375, P > 
      0.05).
FAU - Ma, Y X
AU  - Ma YX
AD  - Department of Aging and Antiaging, Shanghai Institute of Geronotology and 
      Geriatrics, Huadong Hospital, China. du@iris.shlc.ac.cn
FAU - Zhu, Y
AU  - Zhu Y
FAU - Wang, Z S
AU  - Wang ZS
FAU - Wang, C F
AU  - Wang CF
FAU - Chen, S Y
AU  - Chen SY
FAU - Zhao, M T
AU  - Zhao MT
FAU - Zhang, G L
AU  - Zhang GL
FAU - Zheng, S Q
AU  - Zheng SQ
FAU - Zhang, J G
AU  - Zhang JG
FAU - Gu, Q
AU  - Gu Q
FAU - He, L
AU  - He L
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Immunoglobulins)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - *Aging
MH  - Asian People
MH  - Female
MH  - Genotype
MH  - HLA-A Antigens/*blood/classification
MH  - HLA-B Antigens/*blood/classification
MH  - HLA-C Antigens/*blood/classification
MH  - Heterozygote
MH  - Humans
MH  - Immunoglobulins/blood
MH  - *Longevity
MH  - Male
MH  - Middle Aged
MH  - Superoxide Dismutase/blood
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0047-6374(96)01848-9 [pii]
AID - 10.1016/s0047-6374(96)01848-9 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1997 Mar;94(1-3):191-8. doi: 10.1016/s0047-6374(96)01848-9.