PMID- 9149586
OWN - NLM
STAT- MEDLINE
DCOM- 19970603
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 111
IP  - 5
DP  - 1997 May
TI  - Noninvasive measurement of cardiac output by an acetylene uptake technique and 
      simultaneous comparison with thermodilution in ICU patients.
PG  - 1295-300
AB  - A simple, accurate, and noninvasive method of cardiac output measurement can be 
      an extremely useful tool for the clinician and researcher. This study used the 
      acetylene gas uptake technique to measure the absorption of acetylene into the 
      pulmonary circulation during a constant exhalation, which is proportional to the 
      pulmonary capillary blood flow and to the cardiac output, assuming no anatomic 
      shunts. We compared cardiac output measured simultaneously by this and by the 
      standard thermodilution (TD) technique in 21 patients in the ICU with a variety 
      of medical and surgical conditions and a wide range of cardiac outputs. We also 
      compared the two techniques in 19 ambulatory patients with a 2-h interval between 
      the invasive and noninvasive test to assess variability over time. The two tests 
      had an excellent correlation when done simultaneously with a correlation 
      coefficient of 0.89 (p < 0.001). With a 2-h interval between the two tests, the 
      correlation coefficient was 0.66 (p = 0.0018). Nine patients in the simultaneous 
      group had cardiomyopathy. When they were excluded, the correlation coefficient 
      increased to 0.96. Most of these patients had documented tricuspid regurgitation 
      (TR), which may underlie the greater difference between acetylene uptake and TD 
      values, with consistently higher TD values in these patients. This study confirms 
      the correlation between the acetylene uptake and the standard invasive TD 
      techniques in sick patients with various medical and surgical conditions and a 
      wide range of cardiac outputs. Furthermore, we believe this would be a more 
      accurate method for measuring cardiac output in patients with cardiomyopathy and 
      TR because it is based only on pulmonary capillary blood flow.
FAU - Sadeh, J S
AU  - Sadeh JS
AD  - Division of Cardiology, Mount Sinai Medical Center, New York, NY 10029, USA.
FAU - Miller, A
AU  - Miller A
FAU - Kukin, M L
AU  - Kukin ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - OC7TV75O83 (Acetylene)
SB  - IM
MH  - Absorption
MH  - *Acetylene/administration & dosage/blood/pharmacokinetics
MH  - Administration, Inhalation
MH  - Adult
MH  - Aged
MH  - Capillaries/physiology
MH  - *Cardiac Output
MH  - Cardiomyopathies/blood/physiopathology
MH  - Coronary Artery Bypass
MH  - *Critical Care
MH  - Female
MH  - Heart Transplantation/physiology
MH  - Humans
MH  - Liver Transplantation/physiology
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory
MH  - Pulmonary Alveoli/metabolism
MH  - Pulmonary Circulation
MH  - Respiration
MH  - *Thermodilution
MH  - Tricuspid Valve Insufficiency/blood/physiopathology
MH  - Vascular Surgical Procedures
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - S0012-3692(15)46964-8 [pii]
AID - 10.1378/chest.111.5.1295 [doi]
PST - ppublish
SO  - Chest. 1997 May;111(5):1295-300. doi: 10.1378/chest.111.5.1295.