PMID- 9150795
OWN - NLM
STAT- MEDLINE
DCOM- 19970710
LR  - 20131121
IS  - 0065-1281 (Print)
IS  - 0065-1281 (Linking)
VI  - 99
IP  - 1
DP  - 1997 Mar
TI  - Development of hydrogen peroxide (H2O2)-generating oxidases in chick organs with 
      special reference to kidneys.
PG  - 37-45
AB  - The developmental pattern of H2O2-producing oxidases (OX) was studied in chick 
      kidneys (mesonephros, metanephros), intestine, liver, yolk sac and adrenal glands 
      between embryonic days (ED) 5-20 as well as in chick organs after hatching. 
      Sections from snap frozen tissue fixed in cold cacodylate-buffered 2% 
      glutaraldehyde were processed by cerium-DAB-Co-H2O2 methods for benzylamine OX, 
      diamine OX, histamine OX, alpha-hydroxyacid OX, D-amino acid OX (AAOX) and 
      monoamine OX (MAOX). Prenatally, only activities of AAOX and MAOX could be 
      demonstrated. AAOX appeared primarily in the proximal tubular cells of both types 
      of kidneys. In the metanephros the enzyme was also detected in the thick 
      ascending limbs of Henle's loops. The amount of reaction product in tubular cells 
      increased with their maturation. MAOX activity was detected in immature 
      enterocytes, in smooth muscle cells of large systemic arteries (on ED 5-6) as 
      well as in proximal tubular cells of the mesonephros and adrenal gland. Later the 
      enzyme appeared also in smooth muscle cells of the intestinal wall and in 
      endothelial and smooth muscle cells of arterioles of the mesonephros. In the 
      metanephros MAOX was detected at the same locations with a time delay because of 
      a developmental shift of the kidney. Inhibition tests revealed that MAOX differs 
      in epithelial cells from that in smooth muscle cells. Benzylamine OX, diamine OX 
      and histamine OX were detected postnatally in smooth muscle cells of the arterial 
      media and muscularis externa of the intestinal wall with low activities. It is 
      concluded that MAOX and AAOX activities represent useful markers in the 
      development of renal tubules. In addition, MAOX activity can be considered an 
      indicator of maturation of components of the vascular wall.
FAU - Zemanova, Z
AU  - Zemanova Z
AD  - Institute of Physiology, Academy of Sciences of Czech Republic, Prague.
FAU - Gossrau, R
AU  - Gossrau R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Histochem
JT  - Acta histochemica
JID - 0370320
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.4.3.- (Benzylamine Oxidase)
RN  - EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
RN  - EC 1.4.3.3 (D-Amino-Acid Oxidase)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
SB  - IM
MH  - Amine Oxidase (Copper-Containing)/chemistry
MH  - Animals
MH  - Benzylamine Oxidase/chemistry
MH  - Chick Embryo
MH  - D-Amino-Acid Oxidase/chemistry
MH  - Hydrogen Peroxide/chemistry/*metabolism
MH  - Kidney/cytology/embryology/*enzymology
MH  - Monoamine Oxidase/chemistry
MH  - Organ Specificity
MH  - Peroxidases/chemistry/*metabolism
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0065-1281(97)80006-2 [pii]
AID - 10.1016/S0065-1281(97)80006-2 [doi]
PST - ppublish
SO  - Acta Histochem. 1997 Mar;99(1):37-45. doi: 10.1016/S0065-1281(97)80006-2.