PMID- 9150816
OWN - NLM
STAT- MEDLINE
DCOM- 19970707
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 95
IP  - 4
DP  - 1997 Apr
TI  - Adverse effects in epilepsy therapy. Wait and see or go for it?
PG  - 248-52
AB  - OBJECTIVES: Attention for adverse effects (AEs) is important for optimizing 
      epilepsy treatment. However, a uniform strategy is lacking. In particular there 
      appears to be a dichotomy between those who "wait and see" and those who "go for 
      it", i.e. routinely check a list of AEs. Our intention is to identify the effects 
      of different approaches. METHODS: Trial reports on carbamazepine or valproate 
      monotherapy (Medline-search), and data from the Nijmegen Epilepsy Research Group 
      were analyzed. RESULTS: Analysis suggests that for certain AEs, such as diplopia, 
      dysarthria, affect and mood disturbances, headache, dizziness, gastro-intestinal 
      disturbances, dermatological disturbances and idiosyncratic reactions, it does 
      not matter which approach is chosen. However, sedation, cognitive impairments, 
      sexual dysfunction, hair changes, nystagmus, gait disturbances, tremor and weight 
      changes are reported more frequently when routinely checked. The value of routine 
      laboratory monitoring is, however, questioned. CONCLUSIONS: Use of different 
      strategies to detect AEs obstructs estimation of risks of AEDs. Baseline 
      measurements and regular checking for those AEs, which are reported more 
      frequently by authors who actively search for AEs, is advisable.
FAU - Deckers, C L
AU  - Deckers CL
AD  - Institute of Neurology, University Hospital of Nijmegen, The Netherlands.
FAU - Hekster, Y A
AU  - Hekster YA
FAU - Keyser, A
AU  - Keyser A
FAU - Lammers, M W
AU  - Lammers MW
FAU - Meinardi, H
AU  - Meinardi H
FAU - Renier, W O
AU  - Renier WO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Anticonvulsants)
RN  - 33CM23913M (Carbamazepine)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Anticonvulsants/*adverse effects
MH  - Carbamazepine/therapeutic use
MH  - Clinical Trials as Topic
MH  - Epilepsy/*drug therapy
MH  - Humans
MH  - MEDLINE
MH  - Valproic Acid/therapeutic use
RF  - 22
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0404.1997.tb00106.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 1997 Apr;95(4):248-52. doi: 
      10.1111/j.1600-0404.1997.tb00106.x.