PMID- 9151396
OWN - NLM
STAT- MEDLINE
DCOM- 19970701
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 49
IP  - 4
DP  - 1997 Apr
TI  - Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis.
PG  - 421-6
AB  - Presentation of endogenous peptides by major histocompatibility complex class I 
      (MHC) molecules is controlled, in part, by the Tap1 and Tap2 genes in the MHC 
      class II region that encode a heterodimeric peptide transporter. Polymorphisms of 
      human Tap1 in normal individuals have now been investigated systematically by 
      denaturing gradient gel electrophoresis (DGGE) analysis of fragments of genomic 
      DNA generated by the polymerase chain reaction. Polymorphisms identified by 
      distinctive DGGE band patterns were confirmed by DNA sequencing. In addition to 
      four previously described polymorphisms in the open reading frame, DGGE detected 
      three new polymorphisms: a G-->T substitution in the promoter region, a 10-bp 
      insert in intron 9, and a G-->T substitution 80-bp downstream of the translation 
      termination codon.
FAU - Shi, L
AU  - Shi L
AD  - Immunobiology Laboratory, Massachusetts General Hospital, Charlestown, USA.
FAU - Yan, G
AU  - Yan G
FAU - Fu, Y
AU  - Fu Y
FAU - Ma, L
AU  - Ma L
FAU - Penfornis, A
AU  - Penfornis A
FAU - Faustman, D
AU  - Faustman D
LA  - eng
GR  - DE11023A-02/DE/NIDCR NIH HHS/United States
GR  - DE11151A-03/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (TAP1 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Electrophoresis, Polyacrylamide Gel
MH  - *Genes, MHC Class II
MH  - Genome, Human
MH  - Humans
MH  - *Polymorphism, Genetic
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1111/j.1399-0039.1997.tb02772.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1997 Apr;49(4):421-6. doi: 10.1111/j.1399-0039.1997.tb02772.x.