PMID- 9151942
OWN - NLM
STAT- MEDLINE
DCOM- 19970811
LR  - 20220409
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 325
IP  - 1
DP  - 1997 Apr 23
TI  - Pentoxifylline decreases brain levels of platelet activating factor in murine 
      AIDS.
PG  - 81-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) have 
      been implicated in the pathogenesis of human immunodeficiency virus 
      (HIV)-associated encephalopathy. The effects of pentoxifylline on brain PAF 
      levels were examined in mice infected with the LP-BM5 murine leukemia virus 
      (MuLV). Seven weeks after viral inoculation, significant increases in serum 
      TNF-alpha and brain PAF levels were observed. One week of treatment with 
      pentoxifylline initiated 6 weeks postinfection significantly reduced both serum 
      TNF-alpha and brain PAF levels. A significant positive correlation was observed 
      between the levels of these substances (r = 0.62; P < 0.01). This study 
      demonstrates that pentoxifylline treatment was effective in decreasing the levels 
      of TNF-alpha in the serum and PAF levels in the brain of mice infected with the 
      LP-BM5 MuLV.
FAU - Sei, Y
AU  - Sei Y
AD  - Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 
      20892, USA. sei@helix.nih.gov
FAU - Nishida, K
AU  - Nishida K
FAU - Kustova, Y
AU  - Kustova Y
FAU - Markey, S P
AU  - Markey SP
FAU - Morse, H C 3rd
AU  - Morse HC 3rd
FAU - Basile, A S
AU  - Basile AS
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Platelet Activating Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/*metabolism
MH  - Brain Diseases/blood/*metabolism/virology
MH  - Leukemia Virus, Murine
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Murine Acquired Immunodeficiency Syndrome/blood/complications/*metabolism
MH  - Pentoxifylline/*pharmacology
MH  - Phosphodiesterase Inhibitors/*pharmacology
MH  - Platelet Activating Factor/*metabolism/toxicity
MH  - Retroviridae Infections/complications/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Tumor Virus Infections/complications/metabolism
EDAT- 1997/04/23 00:00
MHDA- 2001/03/28 10:01
CRDT- 1997/04/23 00:00
PHST- 1997/04/23 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1997/04/23 00:00 [entrez]
AID - S0014-2999(97)89963-3 [pii]
AID - 10.1016/s0014-2999(97)89963-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1997 Apr 23;325(1):81-4. doi: 10.1016/s0014-2999(97)89963-3.