PMID- 9152962
OWN - NLM
STAT- MEDLINE
DCOM- 19970728
LR  - 20190831
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 95
IP  - 1-2
DP  - 1997 Apr
TI  - Role of glutathione conjugation in protection of weanling rat liver against 
      acetaminophen-induced hepatotoxicity.
PG  - 71-9
AB  - The rate of glutathione (GSH) conjugate formation to acetaminophen (APAP) in 
      livers of weanling and adult rats treated with a single i.p. dose of APAP was 
      compared. HPLC analysis of cytosolic fractions revealed that rate of conjugation 
      in weanling rat is 24-times greater than that of adults. Increased rate of GSH 
      conjugation was independent of of the age-related difference observed in liver 
      GSH content. The normal level of liver GSH in weanling rat was 57% of adult 
      level. APAP treatment depleted GSH more significantly in weanling rats as 
      compared to that in adults. N-acetylcystein (NAC) alone had little influence on 
      liver GSH levels. However it was successful in reducing GSH depletion in tissues 
      of growing rats. A 32% repletion in hepatic GSH level in NAC-treated weanling 
      rats was associated with a further 13-fold increase in the rate of GSH conjugate 
      formation. These data together with histopathological results, clearly showed 
      that the inducible GSH system in weanling rat liver act as a safe guard against 
      APAP toxicity. A surge in the rate of APAP-GSH conjugation in growing liver may 
      function in compensation of other detoxification pathways which are saturated 
      more readily at this age.
FAU - Allameh, A
AU  - Allameh A
AD  - Department of Biochemistry, Faculty of Medical Sciences, Tarbiat Modaress 
      University, Tehran, Iran.
FAU - Vansoun, E Y
AU  - Vansoun EY
FAU - Zarghi, A
AU  - Zarghi A
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
RN  - GAN16C9B8O (Glutathione)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetaminophen/*metabolism/pharmacokinetics/*toxicity
MH  - Acetylcysteine/pharmacology
MH  - Aging/metabolism
MH  - Analgesics, Non-Narcotic/*metabolism/pharmacokinetics/*toxicity
MH  - Animals
MH  - Glutathione/*metabolism
MH  - Inactivation, Metabolic
MH  - Liver/*drug effects/*metabolism
MH  - Male
MH  - Rats
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - S0047-6374(97)01862-9 [pii]
AID - 10.1016/s0047-6374(97)01862-9 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1997 Apr;95(1-2):71-9. doi: 10.1016/s0047-6374(97)01862-9.