PMID- 9154128
OWN - NLM
STAT- MEDLINE
DCOM- 19970626
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 76
IP  - 1-2
DP  - 1997
TI  - The gene cluster containing the LCAT gene is conserved between human and pig.
PG  - 53-7
AB  - A pooled DNA probe from P1 artificial chromosome clones (PACs) containing the 
      human lecithin:cholesterol acyl transferase (LCAT) gene cluster was used in 
      fluorescence in situ hybridization (FISH) experiments assigning the genes to pig 
      chromosome 6p13. In addition, probes derived from the coding regions in the human 
      gene cluster were used in long range mapping experiments to show that the overall 
      structures of the human and porcine LCAT gene clusters are identical. Both the 
      linear order and the close physical distance of five apparently unrelated genes 
      have been maintained throughout 90 million years of divergent evolution between 
      human and pig. The extremely dense clustering of the genes in the LCAT gene 
      cluster suggests that this gene organization has biological significance. The 
      conservation of the gene cluster between human and pig supports this suggestion.
FAU - Frengen, E
AU  - Frengen E
AD  - Biotechnology Centre of Oslo, University of Oslo, Norway. 
      eirik.frengen@biotek.uio.no
FAU - Thomsen, P D
AU  - Thomsen PD
FAU - Brede, G
AU  - Brede G
FAU - Solheim, J
AU  - Solheim J
FAU - de Jong, P J
AU  - de Jong PJ
FAU - Prydz, H
AU  - Prydz H
LA  - eng
SI  - GENBANK/X71874
SI  - GENBANK/X71875
GR  - 1R01RG01165-01/RG/CSR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA, Complementary)
RN  - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - Chromosomes
MH  - *Conserved Sequence
MH  - DNA, Complementary
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Phosphatidylcholine-Sterol O-Acyltransferase/*genetics
MH  - Restriction Mapping
MH  - Swine
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000134515 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1997;76(1-2):53-7. doi: 10.1159/000134515.