PMID- 9154340
OWN - NLM
STAT- MEDLINE
DCOM- 19970716
LR  - 20131121
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 121
IP  - 2
DP  - 1997 May
TI  - Central involvement of kinin B1 and B2 receptors in the febrile response induced 
      by endotoxin in rats.
PG  - 296-302
AB  - 1. The effect of central injection of selective kinin B1 and B2 receptor 
      antagonists on the febrile response induced by endotoxin (E. coli 
      lipopolysaccharide, LPS) in rats was investigated. 2. Intracerebroventricular 
      (i.c.v.) injection of a selective B2 receptor antagonist (Hoe-140, 8 nmol) 
      reduced the early (0-2 h), but increased the late phase (4-6 h) of the febrile 
      response induced by intravenous (i.v.) injection of LPS (0.5 microgram kg-1). 3. 
      Co-administration of Hoe-140 (8 nmol, i.c.v.) with LPS (0.5 microgram kg-1, 
      i.v.), followed 2.5 h later by the i.c.v. injection of a selective B1 receptor 
      antagonist [des-Arg9-Leu8]-bradykinin (BK, 8 nmol), significantly reduced the 
      febrile response induced by LPS throughout the whole experimental period. 4. 
      Intravenous injection of Hoe-140 (1 mg kg-1) significantly reduced the febrile 
      response induced by LPS (0.5 microgram kg-1, i.p.). 5. Pretreatment (24 h) with 
      LPS (0.5 microgram kg-1, i.v.) reduced the febrile response induced by BK or 
      [Tyr8]-BK (both, 5 nmol, i.c.v.), but markedly increased the febrile response 
      induced by [des-Arg9]-BK (5 nmol, i.c.v.). The response induced by [des-Arg9]-BK 
      in LPS-pretreated rats was significantly inhibited by co-injection of 
      [des-Arg9-Leu8]-BK (15 nmol, i.c.v.). 6. The results suggest that kinins are 
      involved in the induction of LPS-induced fever and that central B2 and B1 
      receptors are activated during the initial and late phase of this response, 
      respectively. The results also suggest that downregulation and/or desensitization 
      of B2 receptors and induction and/or upregulation of B1 receptors in 
      LPS-pretreated animals may have a significant pathophysiological role in the 
      induction and maintenance of fever. These observations may be specifically 
      important in the case of chronic inflammatory conditions, because the BK 
      metabolite [des-Arg9]-BK, so far considered an inactive metabolite, acquires an 
      active and relevant role with the progressive expression of B1 receptors that 
      occurs in such states.
FAU - Coelho, M M
AU  - Coelho MM
AD  - Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences of Ribeirao Preto, 
      University of Sao Paulo, Brazil.
FAU - Oliveira, C R
AU  - Oliveira CR
FAU - Pajolla, G P
AU  - Pajolla GP
FAU - Calixto, J B
AU  - Calixto JB
FAU - Pela, I R
AU  - Pela IR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Endotoxins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Bradykinin)
RN  - 7PG89G35Q7 (icatibant)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Animals
MH  - Bradykinin/adverse effects/*analogs & derivatives
MH  - Central Nervous System/*drug effects
MH  - Endotoxins/*pharmacology
MH  - Fever/*physiopathology
MH  - Lipopolysaccharides/*adverse effects
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Bradykinin/*drug effects
PMC - PMC1564670
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
PMCR- 1998/05/01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PHST- 1998/05/01 00:00 [pmc-release]
AID - 0701110 [pii]
AID - 10.1038/sj.bjp.0701110 [doi]
PST - ppublish
SO  - Br J Pharmacol. 1997 May;121(2):296-302. doi: 10.1038/sj.bjp.0701110.