PMID- 9158108
OWN - NLM
STAT- MEDLINE
DCOM- 19970612
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 108
IP  - 2
DP  - 1997 May
TI  - Intravenous immunoglobulin (IVIG) treatment of experimental colitis induced by 
      dextran sulfate sodium in rats.
PG  - 340-5
AB  - We investigated the therapeutic effect and immunological action mechanism of IgG 
      in experimental colitis induced by 3% dextran sulfate sodium in rats. Intravenous 
      injection of homologous (rat) IgG (400 mg/kg per day) caused a significant 
      suppression of occult blood discharge and ulcerative lesions in the colon, while 
      no suppressive effect was observed in the case of heterologous (human) IgG. The 
      positive effect of rat IgG on the lesions was also clearly shown by the 
      histological examinations. Generation of proinflammatory cytokines, i.e. tumour 
      necrosis factor-alpha (TNF-alpha) and IL-1alpha, in the lesions was found to be 
      inhibited by administration of rat IgG. Little or no suppressive action was 
      exerted by human IgG. Careful examination of recruited T cells and macrophages, 
      both of which are thought to play important roles in the development of 
      ulcerative colitis, indicated that rat IgG, but not its human counterpart, 
      decreased the number of immunocompetent cells in colonic mucosa. Meanwhile, in an 
      in vitro study, both forms of IgG were shown to suppress production of TNF-alpha 
      and IL-1alpha from lamina propria mononuclear cells isolated from rat colon. 
      These findings suggest that, mainly by suppressing recruitment of immunocompetent 
      cells into the lesions, homologous IgG may reduce the occurrence of colitis.
FAU - Shintani, N
AU  - Shintani N
AD  - Research Division, The Green Cross Corporation, Osaka, Japan.
FAU - Nakajima, T
AU  - Nakajima T
FAU - Nakakubo, H
AU  - Nakakubo H
FAU - Nagai, H
AU  - Nagai H
FAU - Kagitani, Y
AU  - Kagitani Y
FAU - Takizawa, H
AU  - Takizawa H
FAU - Asakura, H
AU  - Asakura H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Cell Movement/immunology
MH  - Colitis, Ulcerative/chemically induced/*immunology/pathology/*therapy
MH  - Cytokines/biosynthesis
MH  - Dextran Sulfate/*toxicity
MH  - Humans
MH  - Immunization, Passive
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Intestinal Mucosa/immunology/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
PMC - PMC1904641
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
PMCR- 1998/05/01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PHST- 1998/05/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1997.d01-1021.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1997 May;108(2):340-5. doi: 
      10.1046/j.1365-2249.1997.d01-1021.x.