PMID- 9159226
OWN - NLM
STAT- MEDLINE
DCOM- 20060303
LR  - 20211203
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 1
DP  - 1996 Aug 1
TI  - New mechanisms of regulation of the genomic actions of vitamin D in bone cells: 
      interaction of the vitamin D receptor with non-classical response elements and 
      with the multifunctional protein, calreticulin.
PG  - d177-88
AB  - Vitamin D exerts its genomic effects following binding to a specific receptor 
      which is a member of the steroid hormone receptor superfamily. The vitamin D 
      receptor (VDR) forms heterodimers with retinoid X receptors (RXRs) and the dimer 
      then interacts with its cognate binding site, termed vitamin D response element 
      (VDRE), to affect the transcription of target genes. Recent studies have 
      identified novel sequence motifs for VDREs as well as novel protein-protein 
      interactions involving the VDR. These will be reviewed with particular emphasis 
      on the complex VDRE from the c-fos proto-oncogene promoter region and the 
      inhibition of the vitamin D signal transduction pathway by the multifunctional 
      protein, calreticulin. Thus research on the control of gene transcription by 
      vitamin D reveals examples of molecular interplay between transcriptional 
      regulatory pathways and provides new insight into the molecular mechanism of 
      action of vitamin D.
FAU - St-Arnaud, R
AU  - St-Arnaud R
AD  - Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, 
      Montreal, Quebec, Canada H3G1A6. arnaud@shiners.mcgill.ca
FAU - Candeliere, G A
AU  - Candeliere GA
FAU - Dedhar, S
AU  - Dedhar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 19960801
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Calreticulin)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Base Sequence
MH  - Binding Sites
MH  - Bone and Bones/cytology/*physiology
MH  - Calcitriol/physiology
MH  - Calreticulin/genetics/*physiology
MH  - Humans
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Mas
MH  - Receptors, Calcitriol/genetics/*physiology
MH  - Vitamin D/*physiology
RF  - 87
EDAT- 1996/08/01 00:00
MHDA- 2006/03/04 09:00
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 2006/03/04 09:00 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.2741/a124 [doi]
PST - epublish
SO  - Front Biosci. 1996 Aug 1;1:d177-88. doi: 10.2741/a124.