PMID- 9160315
OWN - NLM
STAT- MEDLINE
DCOM- 19970821
LR  - 20171116
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 10
IP  - 5
DP  - 1997 May
TI  - Integrated expression of glomerular extracellular matrix proteins and beta 1 
      integrins in monoclonal light chain-related renal diseases.
PG  - 485-95
AB  - Light-chain deposition disease (LCDD) and amyloid light-chain amyloidosis (AL-Am) 
      represent the two classical diseases associated with glomerular alterations in 
      monoclonal light chain-related renal diseases. LCDD is characterized by 
      deposition of extracellular matrix proteins in the mesangium, thus creating the 
      morphologic appearance recognized as nodular glomerulosclerosis. In AL-Am, the 
      mesangial matrix is replaced by polymerized light chains in the form of amyloid 
      fibrils. Integrins are responsible for cell-to-cell and cell-to-matrix 
      communication and, therefore, are expected to play a key role in the alterations 
      encountered in these two diseases. The present article addresses the expression 
      of selected extracellular matrix proteins (collagen IV, laminin, fibronectin, and 
      tenascin) and their respective receptor beta 1 integrins (alpha 2, alpha 3, alpha 
      5, and alpha 9) in glomeruli with LCDD and AL-Am by immunohistochemical methods. 
      The corresponding integrin (alpha 9 beta 1) co-localized with tenascin in the 
      center of the mesangial nodules in LCDD. In AL-Am, tenascin is found primarily at 
      the periphery of replaced mesangial areas and in the remaining mesangium not 
      replaced by the amyloid. Tenascin co-localized with alpha 9 beta 1 integrin in 
      mesangial areas in the earlier phases of the process. Fibronectin, laminin, and 
      collagen IV, although increased in absolute amounts, are pushed toward the 
      periphery of mesangial areas, in which correlated expression of their 
      corresponding beta 1 integrins (alpha 2, alpha 3, and alpha 5, respectively) is 
      documented in both LCDD and AL-Am. Deposition of tenascin might be at least 
      partially responsible for the perpetuation and irreversibility of the glomerular 
      lesion in LCDD.
FAU - Turbat-Herrera, E A
AU  - Turbat-Herrera EA
AD  - Department of Pathology, Overton Brooks Veterans Administration Medical Center, 
      Shreveport, Louisiana, USA.
FAU - Isaac, J
AU  - Isaac J
FAU - Sanders, P W
AU  - Sanders PW
FAU - Truong, L D
AU  - Truong LD
FAU - Herrera, G A
AU  - Herrera GA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Albumins)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Fibronectins)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 0 (Immunoglobulin lambda-Chains)
RN  - 0 (Immunoglobulins)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Integrin alpha3beta1)
RN  - 0 (Integrin beta1)
RN  - 0 (Integrins)
RN  - 0 (Laminin)
RN  - 0 (Receptors, Collagen)
RN  - 0 (Receptors, Fibronectin)
RN  - 0 (Tenascin)
RN  - 0 (integrin alpha9)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Albumins/metabolism
MH  - Amyloidosis/immunology/metabolism
MH  - Collagen/metabolism
MH  - Extracellular Matrix Proteins/*metabolism
MH  - Fibrinogen/metabolism
MH  - Fibronectins/metabolism
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Immune Complex Diseases/immunology/*metabolism
MH  - Immunoglobulin A/metabolism
MH  - Immunoglobulin G/metabolism
MH  - Immunoglobulin M/metabolism
MH  - Immunoglobulin kappa-Chains/metabolism
MH  - Immunoglobulin lambda-Chains/metabolism
MH  - Immunoglobulins/*metabolism
MH  - Immunohistochemistry
MH  - *Integrin alpha Chains
MH  - Integrin alpha3beta1
MH  - Integrin beta1/metabolism
MH  - Integrins/*metabolism
MH  - Kidney Glomerulus/immunology/*metabolism
MH  - Laminin/metabolism
MH  - Microscopy, Electron
MH  - Receptors, Collagen
MH  - Receptors, Fibronectin/metabolism
MH  - Tenascin/metabolism
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Mod Pathol. 1997 May;10(5):485-95.