PMID- 9163590
OWN - NLM
STAT- MEDLINE
DCOM- 19970619
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 97
IP  - 2
DP  - 1997 May
TI  - Heart transplantation for end-stage heart failure caused by iron overload.
PG  - 293-6
AB  - Few reports exist concerning heart transplantation in recipients with end-stage 
      myocardiopathy-associated heart failure caused by iron overload occurring with 
      beta-thalassaemia, Diamond-Blackfan syndrome or haemochromatosis. Seven potential 
      transplant candidates (six male, one female, mean age 26 years) with such heart 
      failure, following desferrioxamine application subcutaneously over a number of 
      years, and intravenously during their hospitalization before transplantation, 
      were retrospectively analysed. Five were New York Heart Association (NYHA) class 
      IV, three experienced one or more resuscitations immediately before 
      transplantation could be performed. Continuous, high-volume, veno-venous 
      haemofiltration was necessary in two patients. One of these two candidates 
      additionally had to be bridged, first with a right ventricular, then with a 
      biventricular assist device. Five of the seven patients survived, two with 
      haemochromatosis, one with beta-thalassaemia major and one with Diamond-Blackfan 
      syndrome following transplantation. One non-transplanted candidate with 
      beta-thalassaemia major has been recompensated for 5 years. Survival was 14-74 
      months. Our results demonstrate the feasibility and indication of transplantation 
      in patients with such heart failure and the satisfying outcome of 
      immunosuppression is described.
FAU - Koerner, M M
AU  - Koerner MM
AD  - Department of Thoracic and Cardiovascular Surgery, Heart Centre 
      Northrhine-Westphalia, Ruhr University of Bochum, Bad Oeynhausen, Germany.
FAU - Tenderich, G
AU  - Tenderich G
FAU - Minami, K
AU  - Minami K
FAU - zu Knyphausen, E
AU  - zu Knyphausen E
FAU - Mannebach, H
AU  - Mannebach H
FAU - Kleesiek, K
AU  - Kleesiek K
FAU - Meyer, H
AU  - Meyer H
FAU - Koerfer, R
AU  - Koerfer R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomyopathy, Dilated/*therapy
MH  - Fanconi Anemia/*complications
MH  - Female
MH  - *Heart Transplantation/adverse effects
MH  - Hemochromatosis/*complications
MH  - Humans
MH  - Iron Overload/*complications
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
MH  - beta-Thalassemia/*complications
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1997.482693.x [doi]
PST - ppublish
SO  - Br J Haematol. 1997 May;97(2):293-6. doi: 10.1046/j.1365-2141.1997.482693.x.