PMID- 9163865
OWN - NLM
STAT- MEDLINE
DCOM- 19970709
LR  - 20190914
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 10
IP  - 3
DP  - 1997
TI  - Liver transplantation for the treatment of fulminant hepatic failure induced by 
      the ingestion of ecstasy.
PG  - 229-33
AB  - Methylenedimethoxymethamphetamine (MDMA), more commonly known as ecstasy, is a 
      synthetic amphetamine derivative used by teenagers and young adults in the United 
      States as well as in Western Europe as a "dance drug". Though a number of 
      complications associated with this drug have been reported, there is little 
      information pertaining to hepatoxity as a result of MDMA ingestion. This case 
      report is about an 18-year-old female patient who regularly used ecstasy on 
      weekends over a 2-month period. Within 2 days after accepting a "hit" of the 
      substance at a party, she was admitted to the hospital because of lethargy, 
      vomiting, abdominal pain, stool discoloration, icterus, and darkened urine. On 
      day 7 she developed fulminant hepatic failure with reduced hepatic coagulation 
      factors and grade IV encephalopathy. Orthotopic liver transplantation was carried 
      out 10 days following the ingestion. The patient made a full recovery within 72 h 
      and was released from the hospital 6 weeks later. Histopathological examination 
      of the removed liver revealed a nutritive-toxic liver necrosis. This case 
      demonstrates that the ingestion of ecstasy, even on an infrequent basis, can lead 
      to acute fulminant liver necrosis, and that this life-threatening complication 
      can be treated successfully by liver transplantation.
FAU - Brauer, R B
AU  - Brauer RB
AD  - Department of Surgery, Klinikum rechts der Isar, Technical University Munich, 
      Germany.
FAU - Heidecke, C D
AU  - Heidecke CD
FAU - Nathrath, W
AU  - Nathrath W
FAU - Beckurts, K T
AU  - Beckurts KT
FAU - Vorwald, P
AU  - Vorwald P
FAU - Zilker, T R
AU  - Zilker TR
FAU - Schweigart, U
AU  - Schweigart U
FAU - Holscher, A H
AU  - Holscher AH
FAU - Siewert, J R
AU  - Siewert JR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Liver Failure, Acute/chemically induced/*surgery
MH  - *Liver Transplantation
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
RF  - 11
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1007/s001470050047 [doi]
PST - ppublish
SO  - Transpl Int. 1997;10(3):229-33. doi: 10.1007/s001470050047.