PMID- 9167102
OWN - NLM
STAT- MEDLINE
DCOM- 19970724
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 20
IP  - 6
DP  - 1997 Jun
TI  - Contribution of central neuropathy to postural instability in IDDM patients with 
      peripheral neuropathy.
PG  - 929-34
AB  - OBJECTIVE: To evaluate the contribution of central neuropathy on postural 
      impairment observed in diabetic patients with peripheral neuropathy. RESEARCH 
      DESIGN AND METHODS: Central sensory and motor nervous propagation, nerve 
      conduction velocity, and static posturography were assessed in the following 
      age-matched subjects: 7 IDDM patients with peripheral neuropathy (group DN), 18 
      IDDM patients without peripheral neuropathy (group D), and 31 control subjects 
      (group C). Somatosensory-evoked potentials (SEPs) during tibial nerve stimulation 
      were recorded, and the spine-to-scalp sensory central conduction time (SCCT) was 
      evaluated. Motor-evoked potentials (MEPs) were recorded from leg muscles during 
      magnetic transcranial brain stimulation, and the scalp-to-spine motor central 
      conduction time (MCCT) was evaluated. The following posturographic parameters 
      were calculated from the statokinesigram: trace length, trace surface, velocity 
      of body sway with its standard deviation, and VFY (a parameter derived from the 
      velocity variance and the anteroposterior mean position of the body). RESULTS: 
      SCCT was significantly higher in the DN group than in the C and D groups (P < 
      0.001). MCCT was similar in all groups. Posturographic parameters were all 
      significantly impaired in the DN group (P < 0.01). While posturographic 
      parameters showed a direct relationship with some parameters of peripheral nerve 
      conduction, no correlations were observed with SEP and MEP central conduction 
      time. These results were also confirmed by logistic regression, which indicates 
      peripheral neuropathy as the only implicating factor in postural instability 
      (odds ratio 0.22, 95% CI 0.07-0.75) after data reduction by means of factor 
      analysis. CONCLUSIONS: Although diabetic patients with peripheral neuropathy show 
      a delay in central sensory conduction, postural instability may be fully 
      explained by the presence of peripheral neuropathy.
FAU - Uccioli, L
AU  - Uccioli L
AD  - Department of Endocrinology, University of Rome Tor Vergata, Italy.
FAU - Giacomini, P G
AU  - Giacomini PG
FAU - Pasqualetti, P
AU  - Pasqualetti P
FAU - Di Girolamo, S
AU  - Di Girolamo S
FAU - Ferrigno, P
AU  - Ferrigno P
FAU - Monticone, G
AU  - Monticone G
FAU - Bruno, E
AU  - Bruno E
FAU - Boccasena, P
AU  - Boccasena P
FAU - Magrini, A
AU  - Magrini A
FAU - Parisi, L
AU  - Parisi L
FAU - Menzinger, G
AU  - Menzinger G
FAU - Rossini, P M
AU  - Rossini PM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adult
MH  - Brain/physiopathology
MH  - Central Nervous System Diseases/physiopathology
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Diabetic Neuropathies/*physiopathology
MH  - Diabetic Retinopathy
MH  - Evoked Potentials, Motor
MH  - Evoked Potentials, Somatosensory
MH  - Female
MH  - Humans
MH  - Leg
MH  - Male
MH  - Motor Neurons/physiology
MH  - Muscle, Skeletal/innervation
MH  - Neural Conduction
MH  - Neurons, Afferent/physiology
MH  - Peripheral Nervous System Diseases/physiopathology
MH  - Peroneal Nerve/physiopathology
MH  - *Posture
MH  - Proteinuria
MH  - Sural Nerve/physiopathology
MH  - Tibial Nerve/physiopathology
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.2337/diacare.20.6.929 [doi]
PST - ppublish
SO  - Diabetes Care. 1997 Jun;20(6):929-34. doi: 10.2337/diacare.20.6.929.