PMID- 9167950
OWN - NLM
STAT- MEDLINE
DCOM- 19970714
LR  - 20180215
IS  - 0301-0163 (Print)
IS  - 0301-0163 (Linking)
VI  - 47
IP  - 4-6
DP  - 1997
TI  - Multiple endocrine neoplasia type 1 and the search for the genetic trigger.
PG  - 179-84
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is characterized by primary 
      hyperparathyroidism, endocrine pancreatic-duodenal and anterior pituitary tumors. 
      The diagnosis is challenging and involves the exclusion of other endocrine 
      neoplasia syndromes with overlapping features. The predisposing genetic defect 
      was assigned to chromosomal region 11q13 based on linkage analysis. Combined 
      tumor and pedigree genotype analysis showed that allele losses in pancreatic, 
      parathyroid and pituitary tumors eliminated the wild-type allele at the 11q13 
      loci, suggesting inactivation of a tumor suppressor gene in this region. A 5-Mb 
      integrated map of the region has been established by the European consortium on 
      MEN-1. Based on this mapping the critical interval was restricted to 2 Mb, a 
      region within which eight candidate genes are located.
FAU - Farnebo, F
AU  - Farnebo F
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - Jarhult, J
AU  - Jarhult J
FAU - Farnebo, L O
AU  - Farnebo LO
FAU - Nilsson, O
AU  - Nilsson O
FAU - Teh, B T
AU  - Teh BT
FAU - Lagercrantz, J
AU  - Lagercrantz J
FAU - Weber, G
AU  - Weber G
FAU - Sandelin, K
AU  - Sandelin K
FAU - Larsson, C
AU  - Larsson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
SB  - IM
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - Diagnosis, Differential
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Pedigree
RF  - 23
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000185462 [doi]
PST - ppublish
SO  - Horm Res. 1997;47(4-6):179-84. doi: 10.1159/000185462.