PMID- 9168133
OWN - NLM
STAT- MEDLINE
DCOM- 19970616
LR  - 20211203
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 189
IP  - 2
DP  - 1997 Apr 21
TI  - Gene organization of human NOTCH4 and (CTG)n polymorphism in this human 
      counterpart gene of mouse proto-oncogene Int3.
PG  - 235-44
AB  - The cDNA and genomic clones for the human counterpart of the mouse mammary tumor 
      gene Int3 were isolated and sequenced. We designated this human major 
      histocompatibility complex (MHC) class III gene as NOTCH4, since very recently, 
      by sequencing cDNA clones, the complete form of the mouse proto-oncogene Int3 has 
      been clarified and named Notch4. The present human NOTCH4 sequence is the first 
      example of the genomic sequence for the extracellular portion of the mammalian 
      Notch4, and by comparing it with the mouse Notch4 cDNA sequence, the exon/intron 
      organization was clarified. The comparison of the predicted amino acid sequence 
      of human NOTCH4 with those of other Notch homologues of a wide range of species 
      revealed four subfamilies for mammalian Notch. In the protein coding region of 
      human NOTCH4, we found (CTG)n repeats showing a variable number tandem repeat 
      (VNTR) polymorphism for different human leukocyte antigen (HLA) haplotypes. Ten 
      genes mapped on 6p21.3, including NOTCH4, were found to have counterparts 
      structurally and functionally similar to those mostly mapped on 9q33-q34, 
      indicating segmental chromosome duplication during the course of evolution. 
      Similarity of genes on chromosomes 1, 6, 9 and 19 was also discussed.
FAU - Sugaya, K
AU  - Sugaya K
AD  - Genome Research Group, National Institute of Radiological Sciences, Anagawa, 
      Chiba-ken, Japan. k_sugaya@uexs72.nirs.go.jp
FAU - Sasanuma, S
AU  - Sasanuma S
FAU - Nohata, J
AU  - Nohata J
FAU - Kimura, T
AU  - Kimura T
FAU - Fukagawa, T
AU  - Fukagawa T
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Ando, A
AU  - Ando A
FAU - Inoko, H
AU  - Inoko H
FAU - Ikemura, T
AU  - Ikemura T
FAU - Mita, K
AU  - Mita K
LA  - eng
SI  - GENBANK/D63395
SI  - GENBANK/D86566
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (MAS1 protein, human)
RN  - 0 (NOTCH4 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Notch4)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Notch)
RN  - 146991-60-8 (Notch4 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/isolation & purification
MH  - Humans
MH  - Major Histocompatibility Complex/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - *Polymorphism, Genetic
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/chemistry/*genetics
MH  - *Proto-Oncogenes
MH  - Receptor, Notch4
MH  - *Receptors, Cell Surface
MH  - Receptors, Notch
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - *Trinucleotide Repeats
EDAT- 1997/04/21 00:00
MHDA- 1997/04/21 00:01
CRDT- 1997/04/21 00:00
PHST- 1997/04/21 00:00 [pubmed]
PHST- 1997/04/21 00:01 [medline]
PHST- 1997/04/21 00:00 [entrez]
AID - S0378111996008578 [pii]
AID - 10.1016/s0378-1119(96)00857-8 [doi]
PST - ppublish
SO  - Gene. 1997 Apr 21;189(2):235-44. doi: 10.1016/s0378-1119(96)00857-8.