PMID- 9169030
OWN - NLM
STAT- MEDLINE
DCOM- 19970618
LR  - 20231213
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 95
IP  - 2
DP  - 1997 Jun
TI  - Two unbalanced translocations, t(12;22)(p13;q11) and t(12;?)(p13;?), in an 
      aggressive chronic B-cell leukemia: TEL gene analysis using FISH.
PG  - 137-40
AB  - The translocation t(12;22)(p13;q11) has been consistently described in myeloid 
      malignancies and shown to result from a fusion between the TEL and MN1 genes. 
      Previously described deletions of 12p in acute lymphoblastic leukemias have been 
      recently shown to harbor undetected translocations involving the TEL gene at 
      12p13. We document a case of an aggressive chronic B-cell leukemia whose cells 
      had trisomy 12 and two unbalanced translocations involving 12p13, including a 
      t(12;22)(p13;q11) as shown by conventional cytogenetics and fluorescence in situ 
      hybridization (FISH). The 12p13 breakpoint of the t(12;22)(p13;q11) was telomeric 
      to the TEL gene, and the second unbalanced translocation with breakpoint 12p13 
      resulted in the deletion of TEL. This case demonstrates that TEL gene deletions 
      may be relevant in cases of mature B-lymphoproliferative diseases.
FAU - Conchon, M
AU  - Conchon M
AD  - Academic Department of Hematology, Royal Marsden Hospital, London, UK.
FAU - McManus, A P
AU  - McManus AP
FAU - Min, T
AU  - Min T
FAU - Maljaie, S H
AU  - Maljaie SH
FAU - Crawford, A
AU  - Crawford A
FAU - Brito-Babapulle, V
AU  - Brito-Babapulle V
FAU - Matutes, E
AU  - Matutes E
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 22
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/immunology/pathology
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
MH  - Trisomy
MH  - ETS Translocation Variant 6 Protein
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0165460896002579 [pii]
AID - 10.1016/s0165-4608(96)00257-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jun;95(2):137-40. doi: 
      10.1016/s0165-4608(96)00257-9.