PMID- 9169032
OWN - NLM
STAT- MEDLINE
DCOM- 19970618
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 95
IP  - 2
DP  - 1997 Jun
TI  - Identification of chromosome changes in acute myeloid leukemia (AML-M2) by 
      molecular cytogenetics.
PG  - 148-52
AB  - Karyotyping with fluorescence in situ hybridization (FISH) is reported in two 
      rare cases of AML-M2 FAB. In the first case FISH analysis confirmed the presence 
      of a t(7;11)(p15:p15) translocation in a complex karyotype that also showed an 
      unbalanced translocation involving the other chromosome 7, a rare rearrangement 
      between chromosomes 9 and 20, and four or five copies of a small marker derived 
      from chromosome 9. In the second case whole chromosome painting with probes for 
      chromosomes 8, 14, and 21 revealed the presence of a masked t(8;21) translocation 
      in which one chromosome 14 was involved in a newly discovered rearrangement, 
      i.e., t(8;14;21)(q22-q24;q11;q22). Moreover , double color FISH using ETO-CDR P1 
      probe and a cosmid for the 5' part of AML-1 on chromosome 21 showed a two color 
      signal on the 8q-, suggesting a recombination between ETO and AML 1. Molecular 
      cytogenetics overcomes limitation of chromosome banding in the interpretation of 
      complex rearrangements.
FAU - Starza, R L
AU  - Starza RL
AD  - Department of Hematology and Clinical Immunology, University of Perugia, Italy.
FAU - Matteucci, C
AU  - Matteucci C
FAU - Crescenzi, B
AU  - Crescenzi B
FAU - Perla, G
AU  - Perla G
FAU - Carotenuto, M
AU  - Carotenuto M
FAU - Martelli, M F
AU  - Martelli MF
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Mecucci, C
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0165460896002142 [pii]
AID - 10.1016/s0165-4608(96)00214-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jun;95(2):148-52. doi: 
      10.1016/s0165-4608(96)00214-2.