PMID- 9169037
OWN - NLM
STAT- MEDLINE
DCOM- 19970618
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 95
IP  - 2
DP  - 1997 Jun
TI  - Clinical correlations of immunophenotypic variations and the presence of trisomy 
      12 in B-cell chronic lymphocytic leukemia.
PG  - 173-7
AB  - In a prospective study of 93 consecutive untreated patients with B-cell chronic 
      lymphocytic leukemia, we examined the clinical relevance of surface 
      immunoglobulin (sIg) heavy chain (HC) and light chain (LC) isotypes, CD11c or 
      CD25 expression, and the presence of trisomy 12 by fluorescence in situ 
      hybridization (FISH). Careful morphologic evaluation was performed to exclude 
      patients with other forms of chronic lymphoid leukemias, including mantle cell 
      lymphoma, prolymphocytic leukemia, and leukemia phase of lymphoma. In addition, 
      clonally restricted sIg and CD5 surface determinant were expressed in all 
      patients. Clinical presentation, including blood cell counts, clinical stage, and 
      organomegaly, did not correlate with any of the measured variables. After a 
      median follow-up period of 3 years, the particular HC or LC isotype or CD11c 
      expression did not correlate with either disease progression or treatment-free 
      survival. However, trisomy 12 and CD25 expressions were both associated with 
      accelerated disease progression and a shorter treatment-free survival time. Our 
      results confirm the adverse prognostic significance of trisomy 12 expression in 
      chronic lymphocytic leukemia and suggest that CD25 expression may have an 
      unfavorable clinical impact.
FAU - Tefferi, A
AU  - Tefferi A
AD  - Division of Hematology and Internal Medicine, Mayo Medical School, Rochester, MN, 
      USA.
FAU - Bartholmai, B J
AU  - Bartholmai BJ
FAU - Witzig, T E
AU  - Witzig TE
FAU - Jenkins, R B
AU  - Jenkins RB
FAU - Li, C Y
AU  - Li CY
FAU - Hanson, C A
AU  - Hanson CA
FAU - Mesa, R A
AU  - Mesa RA
FAU - Phyliky, R L
AU  - Phyliky RL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
RF  - 28
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S016546089600249X [pii]
AID - 10.1016/s0165-4608(96)00249-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jun;95(2):173-7. doi: 10.1016/s0165-4608(96)00249-x.