PMID- 9169040
OWN - NLM
STAT- MEDLINE
DCOM- 19970618
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 95
IP  - 2
DP  - 1997 Jun
TI  - Acquired monosomy 7 in donor cells in a patient treated for acute lymphoblastic 
      leukemia with bone marrow transplantation.
PG  - 190-7
AB  - Two years after a bone marrow transplant (BMT) from his haploidentical mother, a 
      28-year-old male with a history of acute lymphoblastic leukemia (ALI.) developed 
      myelodysplastic syndrome (MDS) with monosomy 7 in his female bone marrow cells. 
      Follow-up cytogenetic studies, including fluorescence in situ hybridization 
      (FISH) performed twenty-seven and thirty-one months post-BMT consistently showed 
      a female chromosome pattern with monosomy 7. Thirty-six and thirty-nine months 
      post-BMT, further clonal evolution occurred, with the appearance of a sideline of 
      the female cells that first expressed a del(10)(p11.2) and then developed a 
      translocation, t(10;21)(p11.2;q22), in addition to the monosomy 7. Cytogenetic 
      monitoring of this male patient helped to reveal a rare case of early MDS in 
      transplanted donor cells and evolution of the acquired abnormal clone by 
      identifying chromosomal alterations in the donated female bone marrow cells.
FAU - Shekhter-Levin, S
AU  - Shekhter-Levin S
AD  - Department of Human Genetics, University of Pittsburgh, Pennsylvania, USA.
FAU - Bloom, E J
AU  - Bloom EJ
FAU - Swerdlow, S H
AU  - Swerdlow SH
FAU - Sherer, M E
AU  - Sherer ME
FAU - Wald, N
AU  - Wald N
FAU - Gollin, S M
AU  - Gollin SM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - *Chromosomes, Human, Pair 7
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - *Monosomy
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/therapy
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0165460896002634 [pii]
AID - 10.1016/s0165-4608(96)00263-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jun;95(2):190-7. doi: 10.1016/s0165-4608(96)00263-4.