PMID- 9171169
OWN - NLM
STAT- MEDLINE
DCOM- 19970623
LR  - 20161124
IS  - 0022-3085 (Print)
IS  - 0022-3085 (Linking)
VI  - 86
IP  - 6
DP  - 1997 Jun
TI  - Stereotactic biopsy of nonpolar tumors in the dominant hemisphere: a prospective 
      study of effects on language functions.
PG  - 923-6
AB  - A prospective study of patients undergoing computerized tomography (CT)-guided 
      stereotactic biopsy of nonpolar tumors in the dominant hemisphere was undertaken 
      to determine if stereotactic biopsy caused a deterioration of language functions. 
      Language was assessed using the Western Aphasia Battery (WAB) and the Boston 
      Naming Test (BNT) before and after a biopsy sample was obtained. Of 16 patients 
      studied, five (31%) were dysphasic preoperatively. After the biopsy the Aphasia 
      Quotient (AQ), derived from the WAB, had significantly deteriorated in four (80%) 
      of these patients, whereas in the fifth it remained relatively unchanged. One of 
      these patients with an extensive infiltrating hemispheric oligoastrocytoma 
      subsequently recovered normal language function after radiotherapy. In 10 of the 
      11 patients who had normal language function preoperatively there were no 
      deleterious changes after biopsy in either the WAB subtest or BNT scores. In the 
      other patient whose WAB score was normal preoperatively, there was a significant 
      deterioration in postoperative AQ. This patient, who declined steroid therapy 
      before and after biopsy, had a glioblastoma multiforme in Wernicke's area. A 
      postoperative CT scan revealed no changes from what was shown on preoperative 
      scan. This clinical study shows that CT-guided stereotactic biopsy of nonpolar 
      tumors in the dominant hemisphere using the Brown-Roberts-Wells system and the 
      Sedan-Nashold biopsy cannula carries a 9% risk (95% confidence intervals 0-26%) 
      of impairing language functions if the patient is not dysphasic preoperatively. 
      If the patient is dysphasic preoperatively, there is a very high risk of 
      aggravating the dysphasia with stereotactic biopsy.
FAU - Thomson, A M
AU  - Thomson AM
AD  - Department of Clinical Neurosciences, Western General Hospital, Edinburgh, 
      Scotland.
FAU - Taylor, R
AU  - Taylor R
FAU - Fraser, D
AU  - Fraser D
FAU - Whittle, I R
AU  - Whittle IR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy/*methods
MH  - Brain Neoplasms/diagnostic imaging/*pathology/*psychology
MH  - *Dominance, Cerebral
MH  - Glioblastoma/pathology/psychology
MH  - Glioma/diagnostic imaging/pathology/psychology
MH  - Humans
MH  - *Language
MH  - Language Tests
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - *Stereotaxic Techniques
MH  - Tomography, X-Ray Computed
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.3171/jns.1997.86.6.0923 [doi]
PST - ppublish
SO  - J Neurosurg. 1997 Jun;86(6):923-6. doi: 10.3171/jns.1997.86.6.0923.