PMID- 9173954
OWN - NLM
STAT- MEDLINE
DCOM- 19970822
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 82
IP  - 6
DP  - 1997 Jun
TI  - Effect of glucose supplement timing on protein metabolism after resistance 
      training.
PG  - 1882-8
AB  - We determined the effect of the timing of glucose supplementation on fractional 
      muscle protein synthetic rate (FSR), urinary urea excretion, and whole body and 
      myofibrillar protein degradation after resistance exercise. Eight healthy men 
      performed unilateral knee extensor exercise (8 sets/approximately 10 
      repetitions/approximately 85% of 1 single maximal repetition). They received a 
      carbohydrate (CHO) supplement (1 g/kg) or placebo (Pl) immediately (t = 0 h) and 
      1 h (t = +1 h) postexercise. FSR was determined for exercised (Ex) and control 
      (Con) limbs by incremental L-[1-13C]leucine enrichment into the vastus lateralis 
      over approximately 10 h postexercise. Insulin was greater (P < 0.01) at 0.5, 
      0.75, 1.25, 1.5, 1.75, and 2 h, and glucose was greater (P < 0.05) at 0.5 and 
      0.75 h for CHO compared with Pl condition. FSR was 36.1% greater in the CHO/Ex 
      leg than in the CHO/Con leg (P = not significant) and 6.3% greater in the Pl/Ex 
      leg than in the Pl/Con leg (P = not significant). 3-Methylhistidine excretion was 
      lower in the CHO (110.43 +/- 3.62 mumol/g creatinine) than P1 condition (120.14 
      +/- 5.82, P < 0.05) as was urinary urea nitrogen (8.60 +/- 0.66 vs. 12.28 +/- 
      1.84 g/g creatinine, P < 0.05). This suggests that CHO supplementation (1 g/kg) 
      immediately and 1 h after resistance exercise can decrease myofibrillar protein 
      breakdown and urinary urea excretion, resulting in a more positive body protein 
      balance.
FAU - Roy, B D
AU  - Roy BD
AD  - Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
FAU - Tarnopolsky, M A
AU  - Tarnopolsky MA
FAU - MacDougall, J D
AU  - MacDougall JD
FAU - Fowles, J
AU  - Fowles J
FAU - Yarasheski, K E
AU  - Yarasheski KE
LA  - eng
GR  - P41 RR000954/RR/NCRR NIH HHS/United States
GR  - RR-00954/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Keto Acids)
RN  - 0 (Muscle Proteins)
RN  - 816-66-0 (alpha-ketoisocaproic acid)
RN  - AYI8EX34EU (Creatinine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Creatinine/urine
MH  - Glucose/*administration & dosage/pharmacology
MH  - Humans
MH  - Keto Acids/blood
MH  - Male
MH  - Muscle Proteins/*metabolism
MH  - *Physical Fitness
MH  - Time Factors
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1152/jappl.1997.82.6.1882 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1997 Jun;82(6):1882-8. doi: 10.1152/jappl.1997.82.6.1882.