PMID- 9174631
OWN - NLM
STAT- MEDLINE
DCOM- 19970623
LR  - 20190920
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 430
IP  - 5
DP  - 1997 May
TI  - Immunohistochemical analysis of hepatocyte growth factor in human coronary 
      atherectomy specimens: comparison with transforming growth factor beta isoforms.
PG  - 407-15
AB  - The expression and localization of hepatocyte growth factor/scatter factor 
      (HGF/SF) were examined immunohistochemically in 59 human coronary artery lesions 
      retrieved by directional coronary atherectomy and compared with the localization 
      of transforming growth factor beta isoforms (TGF-beta 1, -beta 2, and -beta 3). 
      In 21 of the 59 specimens (35.6%) HGF-like immunoreactivity (HGF-IR) was 
      revealed. The HGF immunopositivity rate of 45% (14/31) in thrombotic tissue was 
      significantly (P < 0.05) higher than the rates of 7.3% (4/55), 7.1% (3/42), and 
      0% (0/14) in fibrous tissue, neointimal hyperplasia and atheromatous gruel, 
      respectively. Immunoreactivity for HGF was much weaker than that for TGF-beta 
      isoforms in these components except in thrombotic tissue. These cells exhibiting 
      strong HGF-IR were inflammatory cells such as monocytes/macrophages in thrombotic 
      tissue, in tissue lesions adjacent to a thrombus, and outside the capillary walls 
      in a portion of the neovascularized lesions. Smooth muscle cells (SMCs) hardly 
      demonstrated HGF-IR. In contrast, in control coronary arteries obtained at 
      autopsy, the HGF-IR was strongly expressed in SMCs. These findings suggest that 
      HGF produced by macrophages play a part in the process of coronary plaque 
      formation attributable to thrombus in man.
FAU - Ueda, H
AU  - Ueda H
AD  - Second Department of Internal Medicine, Hiroshima University School of Medicine, 
      Japan. hiron@mcai.med.hiroshima-u.ac.jp
FAU - Imazu, M
AU  - Imazu M
FAU - Hayashi, Y
AU  - Hayashi Y
FAU - Ono, K
AU  - Ono K
FAU - Yasui, W
AU  - Yasui W
FAU - Yamakido, M
AU  - Yamakido M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Transforming Growth Factor beta)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal/analysis/immunology
MH  - Arteries/*chemistry/metabolism/pathology
MH  - Atherectomy, Coronary
MH  - Coronary Vessels/*chemistry/metabolism/pathology
MH  - Female
MH  - Gene Expression Regulation
MH  - Hepatocyte Growth Factor/*analysis/immunology/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Isomerism
MH  - Macrophages/chemistry/pathology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/chemistry/pathology
MH  - Thrombosis/metabolism/pathology
MH  - Transforming Growth Factor beta/*analysis/chemistry/immunology
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1007/s004280050050 [doi]
PST - ppublish
SO  - Virchows Arch. 1997 May;430(5):407-15. doi: 10.1007/s004280050050.