PMID- 9175595
OWN - NLM
STAT- MEDLINE
DCOM- 19970722
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 226
IP  - 3
DP  - 1997 May 2
TI  - Widespread neuronal expression of c-Fos throughout the brain and local expression 
      in glia following a hippocampal injury.
PG  - 175-8
AB  - Fos oncoprotein is an immediate early gene product and a marker of cell 
      activation following a variety of insults. We have previously shown that a 
      mechanical lesion to the hippocampus of adult mice induces a neuronal expression 
      of the cytokines interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha 
      (TNF alpha) whereas a lesion to the striatum does not. The role of these 
      inflammatory cytokines in the pathophysiology of central neurons is still 
      unclear. The present work was undertaken to study a possible correlation between 
      the central expression patterns of c-Fos on the one hand and IL-1alpha and TNF 
      alpha on the other hand. We show that Fos is expressed in a majority of brain 
      neurons after a unilateral lesion to the hippocampus whereas it is confined to 
      the site of injury when applied to the striatum, as previously described for the 
      expression of the cytokines.
FAU - Tchelingerian, J L
AU  - Tchelingerian JL
AD  - INSERM U-134, Hopital de la Salpetriere, Paris, France.
FAU - Le Saux, F
AU  - Le Saux F
FAU - Pouzet, B
AU  - Pouzet B
FAU - Jacque, C
AU  - Jacque C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Brain/cytology/*metabolism
MH  - Brain Mapping/methods
MH  - Hippocampus/*injuries/metabolism/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Neuroglia/*metabolism
MH  - Neurons/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - Reference Values
EDAT- 1997/05/02 00:00
MHDA- 1997/05/02 00:01
CRDT- 1997/05/02 00:00
PHST- 1997/05/02 00:00 [pubmed]
PHST- 1997/05/02 00:01 [medline]
PHST- 1997/05/02 00:00 [entrez]
AID - S0304-3940(97)00271-1 [pii]
AID - 10.1016/s0304-3940(97)00271-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 1997 May 2;226(3):175-8. doi: 10.1016/s0304-3940(97)00271-1.