PMID- 9175596 OWN - NLM STAT- MEDLINE DCOM- 19970722 LR - 20190701 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 226 IP - 3 DP - 1997 May 2 TI - Modulation of the arterial baroreceptor reflex by the vasopressin receptor in the area postrema of the hypertensive rats. PG - 179-82 AB - The role of arginine8-vasopressin (AVP) in regulation of the baroreceptor reflex in the area postrema was examined in anesthetized hypertensive rats. The sensitivity of the baroreceptor reflex in a one-kidney one clip (1K1C) hypertensive rats was increased in only the initial stage (2 weeks), in association with increase in blood pressure, and then returned to the normal level. This increase in the sensitivity of the baroreceptor reflex in the initial stage was reversed by microinjection of a V1 or V2 antagonist (1 microg) into the area postrema. AVP V2 receptor mRNA was expressed temporarily in the area postrema in this period. These results suggest that vasopressin receptors in the area postrema is important in regulating the sensitivity of the baroreceptor reflex. FAU - Nakayama, Y AU - Nakayama Y AD - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. FAU - Takano, Y AU - Takano Y FAU - Eguchi, K AU - Eguchi K FAU - Migita, K AU - Migita K FAU - Saito, R AU - Saito R FAU - Tsujimoto, G AU - Tsujimoto G FAU - Kamiya, H AU - Kamiya H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Receptors, Vasopressin) SB - IM MH - Animals MH - Blood Pressure/physiology MH - Cerebral Ventricles/*physiology MH - Hypertension/*physiopathology MH - Male MH - Pressoreceptors/*physiology MH - Rats MH - Rats, Inbred SHR MH - Rats, Inbred WKY MH - Rats, Wistar MH - Receptors, Vasopressin/*physiology MH - Reflex/*physiology EDAT- 1997/05/02 00:00 MHDA- 1997/05/02 00:01 CRDT- 1997/05/02 00:00 PHST- 1997/05/02 00:00 [pubmed] PHST- 1997/05/02 00:01 [medline] PHST- 1997/05/02 00:00 [entrez] AID - S0304394097002747 [pii] AID - 10.1016/s0304-3940(97)00274-7 [doi] PST - ppublish SO - Neurosci Lett. 1997 May 2;226(3):179-82. doi: 10.1016/s0304-3940(97)00274-7.