PMID- 9175629
OWN - NLM
STAT- MEDLINE
DCOM- 19970811
LR  - 20190813
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 129
IP  - 1
DP  - 1997 Apr 25
TI  - Retinoid X and retinoic acid receptors interact with transcription factor II-B by 
      distinct mechanisms.
PG  - 55-61
AB  - Nuclear hormone receptors are believed to modulate target gene expression by 
      interacting with the general transcriptional machinery of the cell. We 
      demonstrate here that two otherwise closely related members of the nuclear 
      hormone receptor family, retinoid acid receptors (RARs) and retinoid X receptors 
      (RXRs), exhibit significant differences in their interactions with the 
      transcriptional machinery. RARs display a strong constitutive interaction with 
      transcription factor II-B (TFIIB) that requires the TFIIB C-terminus, whereas RXR 
      exhibits a weaker, hormone-stimulated interaction with the TFIIB that maps 
      outside of the TFIIB C-terminus. Use of a dominant-negative mutant of TFIIB 
      suggests that the TFIIB interaction is essential for full transcriptional 
      activation by RXR.
FAU - Chen, H W
AU  - Chen HW
AD  - Division of Biological Sciences, University of California at Davis, 95616, USA.
FAU - Privalsky, M L
AU  - Privalsky ML
LA  - eng
GR  - R37 CA53394/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factor TFIIB)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Gene Expression Regulation
MH  - Genes, Reporter
MH  - Humans
MH  - Mice
MH  - Receptors, Retinoic Acid/drug effects/genetics/*metabolism
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factor TFIIB
MH  - Transcription Factors/drug effects/genetics/*metabolism
MH  - Transfection
MH  - Tretinoin/pharmacology
EDAT- 1997/04/25 00:00
MHDA- 1997/04/25 00:01
CRDT- 1997/04/25 00:00
PHST- 1997/04/25 00:00 [pubmed]
PHST- 1997/04/25 00:01 [medline]
PHST- 1997/04/25 00:00 [entrez]
AID - S0303-7207(97)04040-9 [pii]
AID - 10.1016/s0303-7207(97)04040-9 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 1997 Apr 25;129(1):55-61. doi: 
      10.1016/s0303-7207(97)04040-9.