PMID- 9176172
OWN - NLM
STAT- MEDLINE
DCOM- 19970708
LR  - 20220318
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 272
IP  - 5 Pt 1
DP  - 1997 May
TI  - Role of the kidney in plasma glucose regulation during hyperglycemia.
PG  - E756-61
AB  - Little is known about the role of the kidney in plasma glucose regulation during 
      hyperglycemia. We studied 12 overnight-fasted conscious dogs after either 
      intrarenal (IR, n = 6) or peripheral (PH, n = 6) dextrose infusion to maintain 
      hyperglycemia without glycosuria. Systemic and renal glucose kinetics were 
      measured with [6-3H]glucose, lactate balance was measured by arteriovenous 
      difference, and glycogen content was assayed in the kidneys. Plasma glucose 
      (approximately 5.5 vs. approximately 6.3 mM), insulin (approximately 70 vs. 
      approximately 110 pM), and glucose appearance (approximately 14 vs. approximately 
      16 mumol.kg-1.min-1 increased comparably in both groups (P < 0.05). In IR, 
      fractional extraction of glucose (FEGlc) increased from 4.1 +/- 0.2 to 16.1 +/- 
      0.5% (P < 0.001) and lactate balance reversed to renal output (+1.3 +/- 0.2 vs. 
      -0.9 +/- 0.2 mumol.kg-1.min-1, P < 0.01). Glycogen content was twofold higher in 
      the left (127 +/- 33 micrograms/g tissue) than in the right kidney (56 +/- 11 
      micrograms/g tissue, P < 0.01). In PH, FEGlc decreased from 4.9 +/- 0.6 to 2.2 
      +/- 0.3% (P < 0.05), renal glucose utilization did not change (approximately 1.3 
      mumol.kg-1.min-1); and glycogen content was equal in both kidneys (approximately 
      45 micrograms/g tissue). We conclude that, although the kidney plays a minor role 
      in plasma glucose disposal in physiological hyperglycemia, increased glucose 
      uptake, glycogen storage, and lactate formation precede glycosuria and may 
      represent important mechanisms by which the kidney contributes to normalization 
      of plasma glucose in diabetes.
FAU - Cersosimo, E
AU  - Cersosimo E
AD  - Department of Medicine, State University of New York at Stony Brook 11794-8154, 
      USA.
FAU - Ajmal, M
AU  - Ajmal M
FAU - Naukam, R J
AU  - Naukam RJ
FAU - Molina, P E
AU  - Molina PE
FAU - Abumrad, N N
AU  - Abumrad NN
LA  - eng
GR  - DK-42562/DK/NIDDK NIH HHS/United States
GR  - DK-49861/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-79-2 (Glycogen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Arteries
MH  - Blood Glucose/*metabolism
MH  - Dogs
MH  - Glucose/metabolism
MH  - Glycogen/metabolism
MH  - Hyperglycemia/*blood/chemically induced
MH  - Kidney/metabolism/*physiology
MH  - Lactic Acid/blood
MH  - Male
MH  - Renal Circulation
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1152/ajpendo.1997.272.5.E756 [doi]
PST - ppublish
SO  - Am J Physiol. 1997 May;272(5 Pt 1):E756-61. doi: 10.1152/ajpendo.1997.272.5.E756.