PMID- 9177776
OWN - NLM
STAT- MEDLINE
DCOM- 19970707
LR  - 20211203
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 42
IP  - 1
DP  - 1997 May 15
TI  - Nucleotide sequence analysis of the HLA class I region spanning the 237-kb 
      segment around the HLA-B and -C genes.
PG  - 55-66
AB  - To elucidate the detailed gene organization of the human leukocyte antigen (HLA) 
      class I region on chromosome 6, seven contiguous cosmid genomic clones covering 
      the 237-kb segment around the HLA-B and -C loci were subjected to DNA sequencing 
      by the shotgun strategy to give a single contig of 236,822 bp from the MICA gene 
      (58.2 kb centromeric of HLA-B) to 90.8 kb telomeric of HLA-C. This region was 
      confirmed to contain four known genes, MICA, HLA-17, HLA-B, and HLA-C, from 
      centromere to telomere. Further, a new member of the P5 multicopy genes was found 
      to be about 1.3 kb upstream of the HLA-17 gene and designated P5.8. Five novel 
      genes designated NOB1-5 were identified by RT-PCR and Northern blot 
      hybridization. In addition, two pseudogenes, dihydrofolate reductase pseudogene 
      (DHFRP) and ribosomal protein L3 homologous gene (RPL3-Hom), were also found in 
      the vicinity of the HLA-B and -C genes, respectively. The two segments (about 40 
      kb) downstream of the HLA-B and HLA-C genes showed high sequence homology to each 
      other, suggesting that segmental genome duplication including the major 
      histocompatibility complex (MHC) class I gene must have occurred during the 
      evolution of the MHC.
FAU - Mizuki, N
AU  - Mizuki N
AD  - Department of Genetic Information, Tokai University School of Medicine, Kanagawa, 
      Japan.
FAU - Ando, H
AU  - Ando H
FAU - Kimura, M
AU  - Kimura M
FAU - Ohno, S
AU  - Ohno S
FAU - Miyata, S
AU  - Miyata S
FAU - Yamazaki, M
AU  - Yamazaki M
FAU - Tashiro, H
AU  - Tashiro H
FAU - Watanabe, K
AU  - Watanabe K
FAU - Ono, A
AU  - Ono A
FAU - Taguchi, S
AU  - Taguchi S
FAU - Sugawara, C
AU  - Sugawara C
FAU - Fukuzumi, Y
AU  - Fukuzumi Y
FAU - Okumura, K
AU  - Okumura K
FAU - Goto, K
AU  - Goto K
FAU - Ishihara, M
AU  - Ishihara M
FAU - Nakamura, S
AU  - Nakamura S
FAU - Yonemoto, J
AU  - Yonemoto J
FAU - Kikuti, Y Y
AU  - Kikuti YY
FAU - Shiina, T
AU  - Shiina T
FAU - Chen, L
AU  - Chen L
FAU - Ando, A
AU  - Ando A
FAU - Ikemura, T
AU  - Ikemura T
FAU - Inoko, H
AU  - Inoko H
LA  - eng
SI  - GENBANK/D20302
SI  - GENBANK/D83543
SI  - GENBANK/D83769
SI  - GENBANK/D83770
SI  - GENBANK/D83771
SI  - GENBANK/D83956
SI  - GENBANK/D83957
SI  - GENBANK/D84394
SI  - GENBANK/F01164
SI  - GENBANK/F02121
SI  - GENBANK/L04965
SI  - GENBANK/L06175
SI  - GENBANK/L14848
SI  - GENBANK/L16869
SI  - GENBANK/L19691
SI  - GENBANK/L25647
SI  - GENBANK/L29406
SI  - GENBANK/L29410
SI  - GENBANK/L29411
SI  - GENBANK/M31944
SI  - GENBANK/M96339
SI  - GENBANK/S70603
SI  - GENBANK/T54086
SI  - GENBANK/T95975
SI  - GENBANK/U17338
SI  - GENBANK/U17339
SI  - GENBANK/U17341
SI  - GENBANK/V00585
SI  - GENBANK/X73460
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (RNA, Messenger)
RN  - 0 (RPL3 protein, human)
RN  - 0 (Ribosomal Protein L3)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Blotting, Northern
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Cloning, Molecular
MH  - Cosmids
MH  - DNA/genetics
MH  - Evolution, Molecular
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/genetics/metabolism
MH  - Restriction Mapping
MH  - Ribosomal Protein L3
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Tissue Distribution
EDAT- 1997/05/15 00:00
MHDA- 1997/05/15 00:01
CRDT- 1997/05/15 00:00
PHST- 1997/05/15 00:00 [pubmed]
PHST- 1997/05/15 00:01 [medline]
PHST- 1997/05/15 00:00 [entrez]
AID - S0888-7543(97)94708-X [pii]
AID - 10.1006/geno.1997.4708 [doi]
PST - ppublish
SO  - Genomics. 1997 May 15;42(1):55-66. doi: 10.1006/geno.1997.4708.