PMID- 9180195
OWN - NLM
STAT- MEDLINE
DCOM- 19970627
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 175
IP  - 6
DP  - 1997 Jun
TI  - Decreased short-term production of tumor necrosis factor-alpha and 
      interleukin-1beta in human immunodeficiency virus-seropositive subjects.
PG  - 1507-10
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were 
      measured by ELISA in 4.5-h, lipopolysaccharide-stimulated whole blood cultures of 
      347 human immunodeficiency virus type 1-infected patients and 107 healthy 
      seronegative controls. The production of TNF-alpha was decreased in both AIDS and 
      non-AIDS patients, whereas the production of IL-1beta was decreased in AIDS 
      patients only. The production of TNF-alpha and IL-1beta was positively affected 
      by the concentrations of CD14+ monocytes and CD8+ lymphocytes; however, in 
      patients, the concentration of CD4+ lymphocytes and the presence of AIDS had a 
      negative effect on cytokine production as determined by multiple linear 
      regression analysis. It is concluded that low whole blood cytokine production is 
      mainly caused by low numbers of cells, but a functional defect may also exist.
FAU - Ullum, H
AU  - Ullum H
AD  - Department of Infectious Diseases and Institute for Inflammation Research, Rhima 
      Centre, Rigshospitalet, Copenhagen, Denmark.
FAU - Victor, J
AU  - Victor J
FAU - Katzenstein, T L
AU  - Katzenstein TL
FAU - Gerstoft, J
AU  - Gerstoft J
FAU - Gotzsche, P C
AU  - Gotzsche PC
FAU - Bendtzen, K
AU  - Bendtzen K
FAU - Skinhoj, P
AU  - Skinhoj P
FAU - Pedersen, B K
AU  - Pedersen BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*blood/immunology
MH  - CD4 Lymphocyte Count
MH  - CD8-Positive T-Lymphocytes
MH  - HIV Seropositivity/*blood/immunology
MH  - *HIV-1
MH  - Humans
MH  - Interleukin-1/*blood
MH  - Lipopolysaccharide Receptors/blood
MH  - Lymphocyte Subsets
MH  - Monocytes/chemistry
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - Viral Load
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1086/516488 [doi]
PST - ppublish
SO  - J Infect Dis. 1997 Jun;175(6):1507-10. doi: 10.1086/516488.